Effects of nicotinic antagonists on working memory performance in young rhesus monkeys.
Effects of nicotinic antagonists on working memory performance in young rhesus monkeys.
复制标题
烟碱拮抗剂对年轻恒河猴的工作记忆表现的影响。
DOI：
10.1016/j.nlm.2021.107505
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发表时间：
2021-10
影响因子：
2.7
通讯作者：
Baxter MG
中科院分区：
文献类型：
--
作者：
Upright NA;Baxter MG
Acetylcholine plays a pivotal neuromodulatory role in the brain, influencing neuronal activity and cognitive function. Nicotinic receptors, particularly α7 and α4β2 receptors, modulate firing of dorsolateral prefrontal (dlPFC) excitatory networks that underlie successful working memory function. Minimal work however has been done examining working memory following systemic blockade of nicotinic receptor systems in nonhuman primates, limiting the ability to explore interactions of other neuromodulatory influences with working memory impairment caused by nicotinic antagonism. In this study, we investigated working memory performance after administering three nicotinic antagonists, mecamylamine, methyllycaconitine, and dihydro-β-erythroidine, in rhesus macaques tested in a spatial delayed response task. Surprisingly, we found that no nicotinic antagonist significantly impaired delayed response performance compared to vehicle. In contrast, the muscarinic antagonist scopolamine reliably impaired delayed response performance in all monkeys tested. These findings suggest there are some limitations on using systemic nicotinic antagonists to probe the involvement of nicotinic receptors in aspects of dlPFC-dependent working memory function, necessitating alternative strategies to understand the role of this system in cognitive deficits seen in aging and neurodegenerative disease.
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影响因子：
25
作者：
Croxson PL;Kyriazis DA;Baxter MG
通讯作者：
Baxter MG
影响因子：
4.7
作者：
Callahan PM;Hutchings EJ;Kille NJ;Chapman JM;Terry AV Jr
通讯作者：
Terry AV Jr
影响因子：
2.5
作者：
Davidson, MC;Marrocco, RT
通讯作者：
Marrocco, RT
影响因子：
3.4
作者：
Hahn, Britta;Shoaib, Mohammed;Stolerman, Ian P.
通讯作者：
Stolerman, Ian P.
DOI：
10.1093/brain/awy099
发表时间：
2018-06-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Sabri O;Meyer PM;Gräf S;Hesse S;Wilke S;Becker GA;Rullmann M;Patt M;Luthardt J;Wagenknecht G;Hoepping A;Smits R;Franke A;Sattler B;Tiepolt S;Fischer S;Deuther-Conrad W;Hegerl U;Barthel H;Schönknecht P;Brust P
通讯作者：
Brust P