Cholinergic modulation of a specific memory function of prefrontal cortex.

Cholinergic modulation of a specific memory function of prefrontal cortex.
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DOI:
10.1038/nn.2971
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发表时间:
2011-11-06
影响因子:
25
通讯作者:
Baxter MG
Baxter MG
中科院分区:
医学1区
文献类型:
--
作者:
Croxson PL;Kyriazis DA;Baxter MG

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前额叶胆碱能功能缺陷与许多神经精神疾病的认知障碍有关,但乙酰胆碱的具体作用尚不清楚。在需要完整的前额叶皮层的决策和情景记忆测试中,选择性地损伤前额叶皮层胆碱能输入的恒河猴没有受到损害,但在空间工作记忆任务中受到严重损害。这些观察结果与前额叶乙酰胆碱在工作记忆中的特定作用相一致。
Deficits in prefrontal cholinergic function are implicated in cognitive impairment in many neuropsychiatric diseases, but acetylcholine’s specific role remains elusive. Rhesus monkeys with selective lesions of cholinergic input to prefrontal cortex were unimpaired in tests of decision-making and episodic memory that require intact prefrontal cortex, but were severely impaired on a spatial working memory task. These observations are consistent with a specific role for prefrontal acetylcholine in working memory.
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