Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation.
Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation.
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启动过程中的视黄酸信号传导允许肠道 CD103+ CD8 TRM 细胞分化。
DOI：
10.1084/jem.20210923
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发表时间：
2023-05-01
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影响因子：
--
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邱等人。证明肠系膜淋巴结 T 细胞启动期间的视黄酸信号传导允许 CD103+ CD8 组织驻留记忆 T 细胞在进入小肠后分化，这可能会改善合理的疫苗设计。 CD8 组织驻留记忆 T (TRM) 细胞为屏障组织提供前线保护；然而，调节 TRM 细胞发育的机制尚不完全清楚。启动决定了效应 T 细胞向组织的迁移，而组织中的因子则诱导原位 TRM 细胞分化。引发是否也调节与迁移无关的原位 TRM 细胞分化尚不清楚。在这里，我们证明肠系膜淋巴结 (MLN) 中的 T 细胞启动调节肠道中 CD103+ TRM 细胞的分化。相比之下，在脾脏中启动的 T 细胞在进入肠道后分化为 CD103+ TRM 细胞的能力受损。 MLN 启动启动了 CD103+ TRM 细胞基因特征，并允许 CD103+ TRM 细胞快速分化以响应肠道中的因素。许可由视黄酸信号传导调节，并且主要由 CCR9 表达和 CCR9 介导的肠道归巢以外的因素驱动。因此，MLN 专门通过原位分化许可来促进肠道 CD103+ CD8 TRM 细胞的发育。
Qiu et al. demonstrate that retinoic acid signaling during T cell priming in the mesenteric lymph nodes licenses the differentiation of CD103+ CD8 tissue-resident memory T cells after entry into the small intestine, which may improve rational vaccine design. CD8 tissue-resident memory T (TRM) cells provide frontline protection at barrier tissues; however, mechanisms regulating TRM cell development are not completely understood. Priming dictates the migration of effector T cells to the tissue, while factors in the tissue induce in situ TRM cell differentiation. Whether priming also regulates in situ TRM cell differentiation uncoupled from migration is unclear. Here, we demonstrate that T cell priming in the mesenteric lymph nodes (MLN) regulates CD103+ TRM cell differentiation in the intestine. In contrast, T cells primed in the spleen were impaired in the ability to differentiate into CD103+ TRM cells after entry into the intestine. MLN priming initiated a CD103+ TRM cell gene signature and licensed rapid CD103+ TRM cell differentiation in response to factors in the intestine. Licensing was regulated by retinoic acid signaling and primarily driven by factors other than CCR9 expression and CCR9-mediated gut homing. Thus, the MLN is specialized to promote intestinal CD103+ CD8 TRM cell development by licensing in situ differentiation.
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DOI：
10.1084/jem.20080039
发表时间：
2008-10-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hammerschmidt SI;Ahrendt M;Bode U;Wahl B;Kremmer E;Förster R;Pabst O
通讯作者：
Pabst O
影响因子：
8.8
作者：
Dodagatta-Marri E;Ma HY;Liang B;Li J;Meyer DS;Chen SY;Sun KH;Ren X;Zivak B;Rosenblum MD;Headley MB;Pinzas L;Reed NI;Del Cid JS;Hann BC;Yang S;Giddabasappa A;Noorbehesht K;Yang B;Dal Porto J;Tsukui T;Niessen K;Atakilit A;Akhurst RJ;Sheppard D
通讯作者：
Sheppard D
影响因子：
8
作者：
Hashimoto-Hill S;Friesen L;Kim M;Kim CH
通讯作者：
Kim CH
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
5.4
作者：
Ericsson, A;Svensson, M;Agace, WW
通讯作者：
Agace, WW