Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation.
Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation.
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感染后，许多因素协调CD8 +效应T细胞和记忆T细胞的数量扩增及分化。利用来自免疫基因组计划的无比广泛的数据，我们分析了感染过程中CD8 + T细胞的转录组，以建立基因表达特征并确定假定的转录调节因子。值得注意的是，我们发现关键基因特征的表达可用于预测CD8 +效应细胞的记忆前体潜能。长寿的记忆CD8 +细胞最终表达一小部分由自然杀伤T细胞和γδ T细胞共享的基因。尽管不同的炎症环境和T细胞前体频率影响CD8 +效应细胞和记忆细胞群的分化，但无论是多克隆还是转基因的，以及无论是对细菌还是病毒模式病原体作出反应，核心转录特征都受到类似的调控。我们的研究结果为影响记忆形成和CD8 + T细胞免疫的转录调控提供了见解。
After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putative transcriptional regulators. Notably, we found that the expression of key gene signatures can be used to predict the memory-precursor potential of CD8+ effector cells. Long-lived memory CD8+ cells ultimately expressed a small subset of genes shared by natural killer T and γδ T cells. Although distinct inflammatory milieu and T cell precursor frequencies influenced the differentiation of CD8+ effector and memory populations, core transcriptional signatures were regulated similarly, whether polyclonal or transgenic, and whether responding to bacterial or viral model pathogens. Our results provide insights into the transcriptional regulation that influence memory formation and CD8+ T cell immunity.
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影响因子：
64.5
作者：
Kaech, SM;Hemby, S;Ahmed, R
通讯作者：
Ahmed, R
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Rutishauser, Rachel L.;Martins, Gislaine A.;Kalachikov, Sergey;Chandele, Anmol;Parish, Ian A.;Meffre, Eric;Jacob, Joshy;Calame, Kathryn;Kaech, Susan M.
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32.4
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通讯作者：
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30.5
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影响因子：
30.5
作者：
Kaech, SM;Tan, JT;Ahmed, R
通讯作者：
Ahmed, R