Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective study.
Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective study.
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DOI：
10.1016/j.clinph.2021.03.016
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Punga AR
中科院分区：
文献类型：
--
作者：
Frithiof R;Rostami E;Kumlien E;Virhammar J;Fällmar D;Hultström M;Lipcsey M;Ashton N;Blennow K;Zetterberg H;Punga AR
目的是描述2019冠状病毒病（COVID-19）重症监护病房获得性虚弱（ICUAW）患者中重症多发性神经病（CIN）和肌病（CIM）的电生理特征和血浆生物标志物。一项观察性ICU队列研究，包括2020年3月13日至6月8日在瑞典乌普萨拉乌普萨拉大学医院入住ICU的成人患者。我们比较了发生CIN/CIM的COVID-19患者与未发生CIN/CIM的患者之间的临床、电生理和血浆生物标志物数据。还比较了COVID-19和非COVID-19 ICU患者的电生理特征。纳入了111名COVID-19患者，其中11名发生CIN/CIM。CIN/CIM患者病情更严重; ICU停留时间更长，血栓栓塞事件更多，更频繁地接受有创通气治疗超过2周。特别是，与非COVID-19队列（0%，p = 0.008）相比，ICUAW的COVID-19患者（50%）中CIN更常见。CIN/CIM组的神经丝轻链（NfL）和胶质细胞酸性蛋白（GFAP）水平高于未发生CIN/CIM组（均p = 0.001），并与神经振幅相关。CIN/CIM在重症COVID-19 ICU患者中更为常见。后来发展为CIN/CIM的COVID-19患者在ICU护理的早期阶段具有显著较高的NfL和GFAP，这表明它们有可能作为CIN/CIM的预测生物标志物。
The aim was to characterize the electrophysiological features and plasma biomarkers of critical illness polyneuropathy (CIN) and myopathy (CIM) in coronavirus disease 2019 (COVID-19) patients with intensive care unit acquired weakness (ICUAW). An observational ICU cohort study including adult patients admitted to the ICU at Uppsala University Hospital, Uppsala, Sweden, from March 13th to June 8th 2020. We compared the clinical, electrophysiological and plasma biomarker data between COVID-19 patients who developed CIN/CIM and those who did not. Electrophysiological characteristics were also compared between COVID-19 and non-COVID-19 ICU patients. 111 COVID-19 patients were included, 11 of whom developed CIN/CIM. Patients with CIN/CIM had more severe illness; longer ICU stay, more thromboembolic events and were more frequently treated with invasive ventilation for longer than 2 weeks. In particular CIN was more frequent among COVID-19 patients with ICUAW (50%) compared with a non-COVID-19 cohort (0%, p = 0.008). Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAp) levels were higher in the CIN/CIM group compared with those that did not develop CIN/CIM (both p = 0.001) and correlated with nerve amplitudes. CIN/CIM was more prevalent among COVID-19 ICU patients with severe illness. COVID-19 patients who later developed CIN/CIM had significantly higher NfL and GFAp in the early phase of ICU care, suggesting their potential as predictive biomarkers for CIN/CIM.
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影响因子：
--
作者：
Tsai, LK;Hsieh, ST;Chang, YC
通讯作者：
Chang, YC
DOI：
10.1186/s13195-018-0339-1
发表时间：
2018-01-23
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Gaetani L;Höglund K;Parnetti L;Pujol-Calderon F;Becker B;Eusebi P;Sarchielli P;Calabresi P;Di Filippo M;Zetterberg H;Blennow K
通讯作者：
Blennow K
影响因子：
158.5
作者：
Herridge, Margaret S.;Tansey, Catherine M.;Cheung, Angela M.
通讯作者：
Cheung, Angela M.
影响因子：
11
作者：
Guarneri, B.;Bertolini, G.;Latronico, N.
通讯作者：
Latronico, N.
影响因子：
3.8
作者：
Kapoor, Mahima;Foiani, Martha;Reilly, Mary M.
通讯作者：
Reilly, Mary M.