The Relationship between Retinol-Binding Protein 4 Concentrations and Gestational Diabetes Mellitus in Chinese Women
The Relationship between Retinol-Binding Protein 4 Concentrations and Gestational Diabetes Mellitus in Chinese Women
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中国女性视黄醇结合蛋白4浓度与妊娠期糖尿病的关系
DOI：
10.1159/000398794
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发表时间：
2015-05
影响因子：
2.1
通讯作者：
Danqing Chen
中科院分区：
文献类型：
--
作者：
Bo Wang;Zhaoxia Liang;Minyue Dong;Danqing Chen
背景：本研究旨在探讨视黄醇结合蛋白4（RBP 4）与妊娠期糖尿病（GDM）的关系。方法：76例GDM患者和非GDM患者。检测空腹血糖（FPG）、空腹胰岛素（Fins）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、糖化血红蛋白（HbA 1c）。结果如下：GDM组RBP 4（21.42 ± 3.846 vs.39.08 ± 8.293 μg/ml）、FPG、Fins、HOMA-IR、HbA 1c、TG水平高于对照组，HDL水平低于对照组（p < 0.01）。在健康对照组中，RBP 4浓度与HOMA-IR和TG正相关，与FPG和HDL负相关（p < 0.05）。GDM孕妇血清RBP 4浓度与TC呈负相关，与孕妇孕期体重增加呈正相关（p < 0.05）。绘制ROC曲线，正确率为93.4%。结论：妊娠期糖尿病妇女血清RPB 4水平显著升高，提示RPB 4水平升高可能在妊娠期糖尿病发病中起一定作用。同时，RBP 4可能是GDM的良好预测因子。RBP 4与TG和HDL相关，表明RBP 4在孕妇脂质代谢的改变中起作用。
Background: This study aimed to investigate the relationship between retinol-binding protein 4 (RBP4) and gestational diabetes mellitus (GDM). Methods: Seventy-six women with and without GDM were recruited. Their blood samples were collected to detect RBP4, fasting plasma glucose (FPG), fasting insulin (Fins), triglyceride (TG), total cholesterol (TC), low-density lipoprotein, high-density lipoprotein (HDL) and glycosylated hemoglobin (HbA1c) levels. Results: RBP4 (21.42 ± 3.846 vs. 39.08 ± 8.293 μg/ml), FPG, Fins, homeostasis model assessment of insulin resistance (HOMA-IR), HbA1c, and TG levels were higher, while HDL levels were lower in women with GDM (p < 0.01). In healthy controls, RBP4 concentrations were positively correlated with HOMA-IR and TG and inversely correlated with FPG and HDL (p < 0.05). Serum concentrations of RBP4 in women with GDM were inversely correlated with TC and positively correlated with maternal weight gain during pregnancy (p < 0.05). The ROC curve was drawn with a correct rate of 93.4%. Conclusions: Concentrations of serum RBP4 were significantly higher in women with GDM, suggesting that elevated RPB4 level may play a role in the pathogenesis of GDM. Meanwhile, RBP4 might be a good predictor of GDM. RBP4 is correlated with TG and HDL, indicating that RBP4 plays a role in alterations of lipid metabolism in pregnant women.
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影响因子：
16.2
作者：
通讯作者：
--
影响因子：
7.7
作者：
通讯作者：
--
影响因子：
16.2
作者：
Y. Cho;Byung-Soo Youn;K. Park
通讯作者：
Y. Cho;Byung-Soo Youn;K. Park
影响因子：
158.5
作者：
Graham, Timothy E.;Yang, Qin;Kahn, Barbara B.
通讯作者：
Kahn, Barbara B.
影响因子：
64.8
作者：
Yang, Q;Graham, TE;Kahn, BB
通讯作者：
Kahn, BB