In Vitro Validation of Patient-Specific Hemodynamic Simulations in Coronary Aneurysms Caused by Kawasaki Disease.
In Vitro Validation of Patient-Specific Hemodynamic Simulations in Coronary Aneurysms Caused by Kawasaki Disease.
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DOI：
10.1007/s13239-014-0184-8
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发表时间：
2014-06-01
影响因子：
1.8
通讯作者：
Marsden, Alison
中科院分区：
文献类型：
--
作者：
Kung, Ethan;Kahn, Andrew M.;Burns, Jane C.;Marsden, Alison
对应用于川崎患者特定冠状动脉瘤解剖结构的计算流体动力学（CFD）进行实验验证。我们量化了生理休息和运动血流条件下患者特定冠状动脉瘤物理模型的血流动力学。使用相位对比MRI（PCMRI），我们获得了动脉瘤中两个层面位置的三分量流速。然后，我们进行了相同的几何形状和入流条件下的数值模拟，并进行定性和定量的实验测量和模拟结果之间的速度比较。我们观察到良好的定性协议的流型特征。PCMRI和CFD之间的定量空间和时间变化的速度差异与流速成正比。因此，无论流速如何变化，模拟和实验之间的百分比差异相对恒定。通过1D和2D定量比较，我们发现测量和模拟速度之间存在5-17%的差异。附加分析评估了可变形壁和刚性壁模拟之间的壁剪切应力差异。这项研究表明，CFD产生良好的定性和定量预测的速度在一个现实的冠状动脉瘤解剖生理流动条件下。结果提供了对可能影响一致性水平的因素的见解，以及一组可供其他人用于与CFD模拟结果进行比较的体外实验数据。本研究的结果增加了使用CFD研究冠状动脉瘤特殊解剖结构中血流动力学的信心。这为将来在川崎患者特异性模型中进行血流动力学研究提供了基础。
To perform experimental validation of computational fluid dynamics (CFD) applied to patient specific coronary aneurysm anatomy of Kawasaki disease. We quantified hemodynamics in a patient-specific coronary artery aneurysm physical phantom under physiologic rest and exercise flow conditions. Using phase contrast MRI (PCMRI), we acquired 3-component flow velocity at two slice locations in the aneurysms. We then performed numerical simulations with the same geometry and inflow conditions, and performed qualitative and quantitative comparisons of velocities between experimental measurements and simulation results. We observed excellent qualitative agreement in flow pattern features. The quantitative spatially and temporally varying differences in velocity between PCMRI and CFD were proportional to the flow velocity. As a result, the percent discrepancy between simulation and experiment was relatively constant regardless of flow velocity variations. Through 1D and 2D quantitative comparisons, we found a 5–17% difference between measured and simulated velocities. Additional analysis assessed wall shear stress differences between deformable and rigid wall simulations. This study demonstrated that CFD produced good qualitative and quantitative predictions of velocities in a realistic coronary aneurysm anatomy under physiological flow conditions. The results provide insights on factors that may influence the level of agreement, and a set of in vitro experimental data that can be used by others to compare against CFD simulation results. The findings of this study increase confidence in the use of CFD for investigating hemodynamics in the specialized anatomy of coronary aneurysms. This provides a basis for future hemodynamics studies in patient-specific models of Kawasaki disease.
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影响因子：
3.6
作者：
Holman, Robert C.;Belay, Ermias D.;Schonberger, Lawrence B.
通讯作者：
Schonberger, Lawrence B.
DOI：
10.1016/j.cma.2005.11.011
发表时间：
2006-01-01
影响因子：
7.2
作者：
Figueroa, C. Alberto;Vignon-Clementel, Irene E.;Taylor, Charles A.
通讯作者：
Taylor, Charles A.
影响因子：
3.8
作者：
Santamarina, A;Weydahl, E;Moore, JE
通讯作者：
Moore, JE
DOI：
10.1002/jmri.1880050608
发表时间：
1995-11-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
McCauley, TR;Pena, CS;Gore, JC
通讯作者：
Gore, JC
DOI：
10.1115/1.2354209
发表时间：
2006-12-01
影响因子：
1.7
作者：
Hoi, Yiemeng;Woodward, Scott H.;Meng, Hui
通讯作者：
Meng, Hui