ANTIBODY TITRES TO A ROUGH-MUTANT STRAIN OF ESCHERICHIA COLI IN PATIENTS UNDERGOING ALLOGENEIC BONE-MARROW TRANSPLANTATION Evidence of a Protective Effect Against Graft-versus-host Disease
ANTIBODY TITRES TO A ROUGH-MUTANT STRAIN OF ESCHERICHIA COLI IN PATIENTS UNDERGOING ALLOGENEIC BONE-MARROW TRANSPLANTATION Evidence of a Protective Effect Against Graft-versus-host Disease
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接受同种异体骨髓移植的患者中大肠杆菌粗突变株的抗体滴度对抗移植物抗宿主病的保护作用的证据
DOI：
10.1016/s0140-6736(87)90700-8
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
V. Aber
中科院分区：
文献类型：
--
作者：
J. Cohen;S. Hashimi;J. Apperley;R. Moore;L. Jones;V. Aber
许多临床和实验证据表明，感染和移植物抗宿主病（GvHD）通常与骨髓移植（BMT）的并发症有关。这种关联的可能基础是革兰氏阴性粪便植物群，这是许多败血症的起源和细菌内毒素的来源，具有强效免疫刺激作用。大肠杆菌J5是一种粗糙的突变菌株，其内毒素只有核心决定因素，而大肠杆菌J5的抗体可以保护动物和人类免受感染性休克的影响。在接受BMT的患者、健康对照者和阻塞性黄疸患者的血清中测定天然存在的大肠杆菌J5抗体（“抗内毒素”）。BMT接受者的滴度显著低于其他两组。此外，IgM类抗J5抗体的滴度与GvHD保护显著相关。
Much clinical and experimental evidence suggests that infection and graft-versus-host disease (GvHD) are commonly associated as complications of bone-marrow transplantation (BMT). A likely basis for this association is the gram-negative faecal flora, the origin of many septicaemias and a source of bacterial endotoxin, which has potent immunostimulatory effects. A rough-mutant strain,Escherichia coliJ5, has only core determinants in its endotoxin, and antibodies to E coli J5 protect animals and human beings from the consequences of septic shock. Naturally occurring antibodies toE coliJ5 ("anti-endotoxin") were assayed in serum from patients undergoing BMT, healthy controls, and patients with obstructive jaundice. BMT recipients had significantly lower titres than the other two groups. Furthermore, the titre of IgM class anti-J5 antibody was significantly associated with protection from GvHD.
用针对突变型大肠杆菌的人抗血清治疗革兰氏阴性菌血症和休克。
DOI：
10.1056/nejm198211113072001
发表时间：
1982
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ziegler,EJ;McCutchan,JA;Fierer,J;Glauser,MP;Sadoff,JC;Douglas,H;Braude,AI
通讯作者：
Braude,AI
使用人类生长激素释放因子治疗的两名儿童的生长加速。
DOI：
10.1056/nejm198501033120102
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
--
作者：
Thorner,MO;Reschke,J;Chitwood,J;Rogol,AD;Furlanetto,R;Rivier,J;Vale,W;Blizzard,RM
通讯作者：
Blizzard,RM