Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer.
Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer.
复制标题
DOI：
10.1080/21655979.2021.2006953
复制
发表时间：
2021-12
期刊：
影响因子：
4.9
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Wang J;Mijiti Y;Chen Y;Liu Z
Aryl hydrocarbon receptor (AHR) plays an important role in tumor development. However, its function in cervical cancer has not been fully elucidated. We evaluated the ten genes that are predicted to associate with AHR protein interaction. The comprehensive scores were: CYP1A1, ARNT2, HSP90AA1, ARNT, AIP, PTGES3, HSP90AB1, CYP1B1, ESR1, MAF, respectively. In addition, we showed that levels of AHR and its related genes were correlated with the immune infiltration and expression of immuno-regulators (immunoinhibitors, immunostimulators, MHC molecules) levels in cervical cancer. High expression of AHR, CYP1A1, HSP90AA1, and HSP90AB1 and low expression of ESR1 were negatively correlated with the prognoses of cervical cancer patients. The Cox multivariate regression showed that high expression of AHR (HR = 1.874, 95% CI = 1.069–3.285, P= 0.028) and CYP1A1 (HR = 1.822, 95%CI = 1.077–3.080, P= 0.025) were risk factors for prognosis in patients with cervical cancer. IHC results indicated that AHR and CYP1A1 were widely expressed in cervical cancer. These findings suggest that AHR and CYP1A1 may serve as prognostic biomarkers for determining prognosis and immune infiltration in cervical cancer.
登录
查看更多内容
影响因子：
3.9
作者：
Formosa R;Borg J;Vassallo J
通讯作者：
Vassallo J
DOI：
10.1073/pnas.1815126116
发表时间：
2019-02-26
影响因子：
11.1
作者：
Kubli, Shawn P.;Bassi, Christian;Gorrini, Chiara
通讯作者：
Gorrini, Chiara
影响因子：
3.3
作者：
Esakky, Prabagaran;Hansen, Deborah A.;Moley, Kelle H.
通讯作者：
Moley, Kelle H.
影响因子：
3.7
作者：
Androutsopoulos, Vasilis P.;Spyrou, Ioannis;Tsatsakis, Aristidis M.
通讯作者：
Tsatsakis, Aristidis M.
影响因子：
78.5
作者：
Murray, Iain A.;Patterson, Andrew D.;Perdew, Gary H.
通讯作者：
Perdew, Gary H.