Cytotoxic Diterpenes from the Root Tuber of Curcuma wenyujin
Cytotoxic Diterpenes from the Root Tuber of Curcuma wenyujin
复制标题
温郁金块茎中的细胞毒性二萜
DOI：
10.1002/hlca.200890100
复制
发表时间：
2008
影响因子：
1.8
通讯作者：
Zhongjun Ma
中科院分区：
文献类型：
--
作者：
Wei Huang;Peng Zhang;Ye;Q. Shi;Yiyu Cheng;Hai;Zhongjun Ma
从温郁金的乙醇提取物中分离得到三个新的二萜化合物，姜黄素醇A-C（1-3），其中2是1的（14 S）-差向异构体。1-3的结构是在光谱分析（主要是核磁共振和MS）的基础上确定的。1-3在体外测试了其对HL-60和K562癌细胞的细胞毒活性。在所测试的化合物中，1个化合物对K-562和HL 60人癌细胞显示中等细胞毒性，IC 50值分别为11.2和3.2 μg/ml。 而2对上述癌细胞的杀伤活性较弱，提示C（14）可能是其细胞毒活性的重要部位。
Bioassay-guided fractionation of ethanolic extract from the root tuber of Curcuma wenyujin afforded three new diterpenes, curcumrinols A–C (1–3), where 2 is the (14S)-epimer of 1. The structures of 1–3 were established on the basis of spectroscopic analysis, mainly NMR and MS. 1–3 were tested in vitro for their cytotoxic activity against the HL-60 and K562 cancer cells. Among the compounds tested, 1 exhibited medium cytotoxicity against K-562 and HL60 human cancer cells with IC50 values of 11.2 and 3.2 μg/ml, respectively. However, 2 showed only weak activity against the above cancers cells, which suggested that C(14) may be an important position for cytotoxic activity.
影响因子：
--
作者：
Tohda, Chihiro;Nakayama, Natsuki;Hatanaka, Fumiyuki;Komatsu, Katsuko
通讯作者：
Komatsu, Katsuko