Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract.
Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract.
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DOI：
10.1093/ecam/nel008
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发表时间：
2006-06
影响因子：
--
通讯作者：
Komatsu, Katsuko
中科院分区：
文献类型：
--
作者：
Tohda, Chihiro;Nakayama, Natsuki;Hatanaka, Fumiyuki;Komatsu, Katsuko
本研究采用小鼠佐剂性关节炎模型，比较6种姜黄属药物的抗炎活性。在注射佐剂前1天口服姜黄甲醇提取物，可显著抑制佐剂性关节炎小鼠的足肿胀和血清结合珠蛋白浓度。此外，当在注射佐剂后1天口服给药时，姜黄的甲醇提取物显著抑制爪肿胀。其他姜黄属植物（姜黄、温郁金、广西姜黄、莪术和郁金）对抗炎剂诱导的足肿胀无明显抑制作用。环氧化酶（考克斯-2）活性被C.黑猩猩姜黄素类化合物（姜黄素、双脱甲氧基姜黄素和脱甲氧基姜黄素）富含C。longa，而C. phaeoacetyl和C. aromatica，而不是C. wenyujin，C. kwangsiensis和C.提示姜黄素类化合物的含量与抑制关节炎肿胀无关。因此，C.姜黄素可能是姜黄属植物中治疗急性炎症的有效药物，而姜黄素的活性成分可能是姜黄属植物中治疗急性炎症的有效成分。姜黄素不是类姜黄素。
We aimed to compare the anti-inflammatory activities of six species of Curcuma drugs using adjuvant arthritis model mice. When orally administered 1 day before the injection of adjuvant, the methanol extract of Curcuma phaeocaulis significantly inhibited paw swelling and the serum haptoglobin concentration in adjuvant arthritis mice. Also when orally administered 1 day after the injection of adjuvant, the methanol extract of Curcuma phaeocaulis significantly inhibited paw swelling. Other Curcuma species (Curcuma longa, Curcuma wenyujin, Curcuma kwangsiensis, Curcuma zedoaria and Curcuma aromatica) had no significant inhibitory effects on adjuvant-induced paw swelling. Cyclooxygenase (COX)-2 activity was significantly inhibited by the methanol extract of C. phaeocaulis. Curcuminoids' (curcumin, bis-demethoxycurcumin and demethoxycurcumin) were rich in C. longa, but less in C. phaeocaulis and C. aromatica, not in C. wenyujin, C. kwangsiensis and C. zedoaria, suggesting that curcuminoids' contents do not relate to inhibition of arthritis swelling. Therefore, C. phaeocaulis may be a useful drug among Curcuma species for acute inflammation, and the active constituents of C. phaeocaulis are not curcuminoids.
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影响因子：
--
作者：
Crofford, LJ;Tan, B;Hla, T
通讯作者：
Hla, T
影响因子：
3.5
作者：
Deshpande, SS;Lalitha, VS;Maur, GB
通讯作者：
Maur, GB
DOI：
10.1016/j.bbrc.2003.12.008
发表时间：
2004-01-16
影响因子：
3.1
作者：
do Nascimento, CO;Hunter, L;Trayhurn, P
通讯作者：
Trayhurn, P
影响因子：
4.7
作者：
Hong, JI;Bose, M;Yang, CS
通讯作者：
Yang, CS
影响因子：
1.7
作者：
OZAKI, Y
通讯作者：
OZAKI, Y