Differential involvement of two cortical masticatory areas in modulation of the swallowing reflex in rats
Differential involvement of two cortical masticatory areas in modulation of the swallowing reflex in rats
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两个皮质咀嚼区在调节大鼠吞咽反射中的差异参与
DOI：
10.1016/j.neulet.2012.09.005
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发表时间：
2012
期刊：
影响因子：
2.5
通讯作者：
M Inoue
中科院分区：
文献类型：
--
作者：
T Tsujimura;K Tsuji;S Ariyasinghe;T Fukuhara;A Yamada;H Hayashi;Y Nakamura;K Iwata;M Inoue
为了阐明皮层下行输入信号在吞咽反射中的功能作用，研究了电刺激两个皮层咀嚼区（A区和p区）对节律性下颚运动（RJMs）和喉上神经（SLN）引起的吞咽反应的影响。反复电刺激cma和SLN分别引起RJMs和吞咽反射。记录近颌肌（咬肌）、开颌肌（二腹肌）和喉提肌（甲状腺舌骨肌）的肌电图活动，以识别rms和吞咽反射。与未刺激组相比，a区刺激组被唤醒的燕子数量显著减少，吞咽间隔显著延长。相反，在p区刺激过程中，这些参数没有明显改变。a区刺激对燕子的抑制作用不受上下牙间木棒刺激增加感觉输入的影响，也不受SLN刺激前a区刺激的影响。目前的研究结果表明，吞咽反射通过激活a区而不是p区来抑制。由于在口腔内感觉输入增加和咀嚼中枢模式发生器（咀嚼中枢模式发生器）事先激活后，吞咽没有变化，吞咽抑制可能是由a区直接输入或通过咀嚼中枢模式输入到吞咽中枢模式输入介导的。
To clarify the functional role of cortical descending inputs involved in the swallowing reflex, the effect of electrical stimulation of two cortical masticatory areas (CMAs: A- and P-area) on rhythmic jaw movements (RJMs) and superior laryngeal nerve (SLN)-evoked swallows were studied. RJMs and swallowing reflex were elicited by repetitive electrical stimulation of CMAs and the SLN, respectively. The electromyographic activities of jaw-closer (masseter), jaw-opener (digastric), and laryngeal-elevator (thyrohyoid) muscles were recorded to identify the RJMs and swallowing reflex. The number of evoked swallows was significantly lower, and swallowing interval was significantly longer during A-area stimulation compared with those without stimulation. Conversely, these parameters were not significantly altered during P-area stimulation. The inhibition of swallows by A-area stimulation was not affected by an increase in sensory input by wooden stick application between upper and lower teeth, or A-area stimulation preceding SLN stimulation. The present findings suggest that the swallowing reflex is inhibited by activation of the A-area, but not the P-area. Since no changes in swallows were seen after the increase in intraoral sensory input and prior activation of masticatory central pattern generator (CPG), swallowing inhibition may be mediated by direct inputs from the A-area or inputs via the masticatory CPG into the swallowing CPG.
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DOI：
--
发表时间：
1987
期刊：
Comparative biochemistry and physiology. A, Comparative physiology
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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C. Roman
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DOI：
--
发表时间：
2007
期刊：
影响因子：
--
作者：
Satoh Y;Ishizuka K;Murakami T
通讯作者：
Murakami T
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影响因子：
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作者：
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通讯作者：
Takako Sato
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影响因子：
3
作者：
K. Ito;M. Morikawa;K. Inenaga
通讯作者：
K. Inenaga