Early plasma soluble receptor for advanced glycation end-product levels are associated with bronchiolitis obliterans syndrome.
Early plasma soluble receptor for advanced glycation end-product levels are associated with bronchiolitis obliterans syndrome.
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DOI：
10.1111/ajt.12062
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Christie JD
中科院分区：
文献类型：
--
作者：
Shah RJ;Bellamy SL;Lee JC;Cantu E;Diamond JM;Mangalmurti N;Kawut SM;Ware LB;Christie JD
肺移植术后早期上皮损伤可能导致闭塞性细支气管炎综合征（BOS）的发生。我们评估了术后早期晚期糖基化终产物可溶性受体（sCRP）水平（一种I型肺泡细胞损伤的标志物）与BOS之间的关系。我们对宾夕法尼亚大学2002年至2006年间的106例肺移植受者进行了队列研究，随访至2010年。移植后6小时和24小时测定血浆胆红素。采用考克斯比例风险模型评价severity与根据ISHLT指南定义的至BOS时间之间的相关性。60例（57%）受试者发生BOS。BOS的平均时间为3.4年。在6小时（HR/SD的血清学水平：1.69，95% CI：1.11，2.57，p=0.02）和24小时（HR/SD的血清学水平：1.74，95% CI：1.14，2.65，p=0.01）测量的血清学水平与BOS风险增加相关。多变量考克斯回归分析表明，这种关系是独立的潜在混杂因素。在术后即刻测量的血浆胆红素水平升高与BOS的发生相关。移植后早期上皮损伤可能是BOS纤维化发生的原因之一。
Early epithelial injury after lung transplantation may contribute to development of bronchiolitis obliterans syndrome (BOS). We evaluated the relationship between early post-operative soluble receptor for advanced glycation end product (sRAGE) levels, a marker of type I alveolar cell injury, and BOS. We performed a cohort study of 106 lung transplant recipients between 2002 and 2006 at the University of Pennsylvania with follow-up through 2010. Plasma sRAGE was measured 6 and 24 hours after transplantation. Cox proportional hazards models were used to evaluate the association between sRAGE and time to BOS, defined according to ISHLT guidelines. Sixty (57%) subjects developed BOS. The average time to BOS was 3.4 years. sRAGE levels measured at 6 hours (HR per SD of sRAGE: 1.69, 95% CI: 1.11, 2.57, p=0.02) and 24 hours (HR per SD of sRAGE: 1.74, 95% CI: 1.14, 2.65, p=0.01) were associated with an increased hazard of BOS. Multivariable Cox regression indicated this relationship was independent of potential confounders. Elevated plasma sRAGE levels measured in the immediate post-operative period are associated with the development of BOS. Early epithelial injury after transplantation may contribute to the development of fibrosis in BOS.
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DOI：
10.1152/ajplung.00075.2007
发表时间：
2007-12-01
影响因子：
4.9
作者：
He, Mei;Kubo, Hiroshi;Yamaya, Mutsuo
通讯作者：
Yamaya, Mutsuo
影响因子：
4.9
作者：
Pullerits R;Bokarewa M;Dahlberg L;Tarkowski A
通讯作者：
Tarkowski A
影响因子：
3.7
作者：
Palmer SM;Flake GP;Kelly FL;Zhang HL;Nugent JL;Kirby PJ;Foley JF;Gwinn WM;Morgan DL
通讯作者：
Morgan DL
影响因子：
--
作者：
Buckley ST;Ehrhardt C
通讯作者：
Ehrhardt C
DOI：
10.1164/rccm.201004-0593oc
发表时间：
2011-01-01
影响因子：
24.7
作者：
Eberlein, Michael;Permutt, Solbert;Brower, Roy G.
通讯作者：
Brower, Roy G.