Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets.
Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets.
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DOI：
10.1016/j.biopha.2021.112420
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Tayebi L
中科院分区：
文献类型：
--
作者：
Farahani M;Niknam Z;Mohammadi Amirabad L;Amiri-Dashatan N;Koushki M;Nemati M;Danesh Pouya F;Rezaei-Tavirani M;Rasmi Y;Tayebi L
解读严重急性呼吸道综合征冠状病毒（SARS-CoV）-2感染的分子下游后果对于更好地了解疾病和治疗计划非常重要。此外，更深入地了解诊断和治疗策略的潜在机制有助于开发针对COVID-19的疫苗和药物。目前，对SARS-CoV-2在宿主细胞中的分子机制还不十分清楚。考虑到SARS-CoV-2与β-CoV的其他成员之间存在的相似性，提出了一些机制，并根据SARS-CoV-2的结构和功能的研究进展解释了其他机制。本文综述了SARS-CoV-2感染后宿主反应的可能机制，并从体外、体内和人体观察等方面综述了目前的研究进展，以及现有的建议。我们讨论了可以引起细胞因子风暴的特定信号事件，并证明了病毒感染后细胞死亡信号的三种形式，包括凋亡，焦亡和坏死。鉴于引发的信号通路，我们引入了可能的基于通路的治疗靶点;特别强调了ADAM 17是参与COVID-19免疫发病机制的几种信号通路中最重要的元素之一。我们还提供了针对这些靶点的可能的候选药物。此外，通过对SARS-CoV-2感染的途径-途径相互作用分析，发现嘌呤-细胞因子受体相互作用途径是重要的串扰途径之一。
Deciphering the molecular downstream consequences of severe acute respiratory syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of the disease and treatment planning. Furthermore, greater understanding of the underlying mechanisms of diagnostic and therapeutic strategies can help in the development of vaccines and drugs against COVID-19. At present, the molecular mechanisms of SARS-CoV-2 in the host cells are not sufficiently comprehended. Some of the mechanisms are proposed considering the existing similarities between SARS-CoV-2 and the other members of the β-CoVs, and others are explained based on studies advanced in the structure and function of SARS-CoV-2. In this review, we endeavored to map the possible mechanisms of the host response following SARS-CoV-2 infection and surveyed current research conducted by in vitro, in vivo and human observations, as well as existing suggestions. We addressed the specific signaling events that can cause cytokine storm and demonstrated three forms of cell death signaling following virus infection, including apoptosis, pyroptosis, and necroptosis. Given the elicited signaling pathways, we introduced possible pathway-based therapeutic targets; ADAM17 was especially highlighted as one of the most important elements of several signaling pathways involved in the immunopathogenesis of COVID-19. We also provided the possible drug candidates against these targets. Moreover, the cytokine-cytokine receptor interaction pathway was found as one of the important cross-talk pathways through a pathway-pathway interaction analysis for SARS-CoV-2 infection.
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DOI：
10.3390/molecules26040944
发表时间：
2021-02-10
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Calligaris M;Cuffaro D;Bonelli S;Spanò DP;Rossello A;Nuti E;Scilabra SD
通讯作者：
Scilabra SD
影响因子：
5.6
作者：
Batra N;De Souza C;Batra J;Raetz AG;Yu AM
通讯作者：
Yu AM
影响因子：
3.8
作者：
Avdeev SN;Trushenko NV;Tsareva NA;Yaroshetskiy AI;Merzhoeva ZM;Nuralieva GS;Nekludova GV;Chikina SY;Gneusheva TY;Suvorova OA;Shmidt AE
通讯作者：
Shmidt AE
COVID-19的防治：重点关注干扰素、氯喹/羟氯喹、阿奇霉素和疫苗
DOI：
10.1016/j.biopha.2020.111008
发表时间：
2021-01
期刊：
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
影响因子：
--
作者：
Bakadia BM;He F;Souho T;Lamboni L;Ullah MW;Boni BO;Ahmed AAQ;Mukole BM;Yang G
通讯作者：
Yang G
影响因子：
10.9
作者：
Arnaldez, Fernanda, I;O'Day, Steven J.;Ascierto, Paolo Antonio
通讯作者：
Ascierto, Paolo Antonio