Prevalence of acute kidney injury (AKI) in extremely low gestational age neonates (ELGAN).
Prevalence of acute kidney injury (AKI) in extremely low gestational age neonates (ELGAN).
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DOI：
10.1007/s00467-020-04563-x
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
PENUT Trial Consortium
中科院分区：
文献类型：
--
作者：
Askenazi DJ;Heagerty PJ;Schmicker RH;Griffin R;Brophy P;Juul SE;Mayock DE;Goldstein SL;Hingorani S;PENUT Trial Consortium
目的：探讨极低胎龄新生儿（ELGAN）不同时期急性肾损伤（AKI）的发生率和严重程度与胎龄（GA）和出生体重（BW）的关系。我们的假设是具有较低GA和较低BW的ELGAN具有较高的AKI发生率。923名参加早产儿促红细胞生成素神经保护试验的ELGAN从出生到死亡或出院进行了评估。AKI的定义是根据肾脏疾病：从临床来源的血清肌酐（SCr）测量改善总体结局（KDIGO）定义。重度AKI定义为2期或以上。在整个队列中，351/923 （38.0%,CI = 34.8-41.3%）至少有一次1期或以上AKI发作，168/923 （18.2%,CI = 15.7-20.7%）至少有一次严重（2期或以上）AKI发作。整个队列在随访早期（3-7天）、中期（8-14天）和后期（14天后）AKI 1期或以上的患病率分别为112/923 （12.1%,CI = 10.0-14.3%）、142/891 （15.9%,CI = 13.5-18.4%）和249/875 （28.5%,CI = 25.4-31.5%）。24、25、26和27周GA组住院期间严重AKI发生率分别为27.8%、21.9%、13.6%和9.4%。在规定的时间趋势下，随着GA和BW的降低，AKI发生率显著升高（使用趋势检验，p < 0.01）。在ELGAN患者最初的住院过程中，AKI相对常见，并与较低的GA和BW相关。
To determine the prevalence and severity of acute kidney injury (AKI) at different time frames in relation to gestational age (GA) and birthweight (BW) in extremely low gestational age neonates (ELGAN). Our hypothesis is that ELGAN with lower GA and lower BW have higher AKI rates. 923 ELGAN enrolled in the Preterm Erythropoietin Neuroprotection Trial were evaluated from birth until death or hospital discharge. AKI was defined according to kidney disease: improving global outcomes (KDIGO) definition from clinically-derived serum creatinine (SCr) measurements. Severe AKI was defined as stage 2 or higher. For the entire cohort, 351/923 (38.0%, CI = 34.8–41.3%) had at least one episode of stage 1 or higher AKI and 168/923 (18.2%, CI = 15.7–20.7%) had at least one episode of severe (stage 2 or higher) AKI. The prevalence of AKI stage 1 or higher for the entire cohort during the early (days 3–7), middle (days 8–14) and late follow-up period (after day 14) was 112/923 (12.1%, CI = 10.0–14.3%), 142/891 (15.9%, CI = 13.5–18.4%) and 249/875 (28.5%, CI = 25.4–31.5%), respectively. The rates of severe AKI during the hospital course were 27.8%, 21.9%, 13.6%, and 9.4% for the 24, 25, 26 and 27 week GA groups respectively. AKI rates were significantly higher with decreasing GA and decreasing BW for stated time trends (all p < 0.01 using tests for trend). AKI is relatively common in ELGAN during their initial hospital course, and is associated with lower GA and BW.
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DOI：
10.1056/nejmoa1611391
发表时间：
2017-01-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Kaddourah A;Basu RK;Bagshaw SM;Goldstein SL;AWARE Investigators
通讯作者：
AWARE Investigators
DOI：
10.1016/s2352-4642(17)30069-x
发表时间：
2017-11
期刊：
The Lancet. Child & adolescent health
影响因子：
--
作者：
Jetton JG;Boohaker LJ;Sethi SK;Wazir S;Rohatgi S;Soranno DE;Chishti AS;Woroniecki R;Mammen C;Swanson JR;Sridhar S;Wong CS;Kupferman JC;Griffin RL;Askenazi DJ;Neonatal Kidney Collaborative (NKC)
通讯作者：
Neonatal Kidney Collaborative (NKC)
DOI：
10.2215/cjn.05190514
发表时间：
2014-12-01
影响因子：
9.8
作者：
Carmody, J. Bryan;Swanson, Jonathan R.;Charlton, Jennifer R.
通讯作者：
Charlton, Jennifer R.
影响因子：
3
作者：
Stojanovic, Vesna;Barisic, Nenad;Doronjski, Aleksandra
通讯作者：
Doronjski, Aleksandra
影响因子：
3
作者：
Viswanathan, Sreekanth;Manyam, Bindu;Mhanna, Maroun J.
通讯作者：
Mhanna, Maroun J.