Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imaging.
Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imaging.
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超声造影评价高尿酸血症肾病肾微灌注
DOI：
10.1242/dmm.049382
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发表时间：
2022-07-01
影响因子：
4.3
通讯作者：
中科院分区：
文献类型：
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作者：
目前尚缺乏早期诊断高尿酸血症所致肾损伤的方法。在此，我们研究了超声造影（CEUS）是否可以作为高尿酸血症性肾病（HN）的诊断工具。在HN大鼠模型中，CEUS检测到肾皮质灌注与对照大鼠相比显著下降。峰值强度（PI）值与HN大鼠血清KIM-1水平和纤维化评分显著相关。与对照组相比，在伴有HN的慢性肾脏病（CKD）1期患者中也观察到PI值早期下降（61.1±4.52 dB vs 65.80±7.10 dB），并且与HN患者的肾功能相关。相比之下，在CKD 1期HN患者中检测到达到PI值的时间增加（15.14±1.75 s vs 14.52±4.75 s），并且在CKD 4期患者中更明显（67.32±3.29 s）。CEUS能够检测到早期CKD合并HN患者的异常肾脏灌注，这与肾功能下降相关，表明CEUS可以作为评估HN患者肾功能的无创工具。
ABSTRACT Diagnostic tools for the early detection of renal injury caused by hyperuricemia are still lacking. Here, we investigated whether contrast-enhanced ultrasound (CEUS) could be used as a diagnostic tool for hyperuricemic nephropathy (HN). In the HN rat model, CEUS detected a significant decline in renal cortical perfusion compared with that in control rats. Peak intensity (PI) values correlated significantly with serum KIM-1 levels and fibrosis scores in HN rats. An early decline in PI values was also observed in chronic kidney disease (CKD) stage 1 patients with HN compared with the controls (61.1±4.52 dB versus 65.80±7.10 dB) and correlated with renal function in the patients with HN. In contrast, an increase in time to reach PI values was detected in HN patients with stage 1 CKD (15.14±1.75 s versus 14.52±4.75 s) and was more pronounced in CKD stage 4 patients (67.32±3.29 s). CEUS was able to detect abnormal renal perfusion in early CKD with HN, which correlated with renal function decline, suggesting that CEUS could be used as a noninvasive tool for assessing renal function in patients with HN.
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影响因子：
19.6
作者：
Khosla, UM;Zharikov, S;Johnson, RJ
通讯作者：
Johnson, RJ
对比增强的超声检查，以评估去甲肾上腺素引起的肾皮质微循环的变化：一项初步研究。
DOI：
10.1186/s13054-014-0653-3
发表时间：
2014-12-02
期刊：
Critical care (London, England)
影响因子：
--
作者：
Schneider AG;Goodwin MD;Schelleman A;Bailey M;Johnson L;Bellomo R
通讯作者：
Bellomo R
影响因子：
13.2
作者：
Iseki, K;Ikemiya, Y;Takishita, S
通讯作者：
Takishita, S
影响因子：
6.1
作者：
Schneider, Antoine G.;Hofmann, Lucie;Vogt, Bruno
通讯作者：
Vogt, Bruno
DOI：
10.1053/j.ajkd.2017.12.009
发表时间：
2018-06
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Johnson RJ;Bakris GL;Borghi C;Chonchol MB;Feldman D;Lanaspa MA;Merriman TR;Moe OW;Mount DB;Sanchez Lozada LG;Stahl E;Weiner DE;Chertow GM
通讯作者：
Chertow GM