Atrial natriuretic peptide in umbilical cord blood: evidence for a circulating hormone in human fetus.
Atrial natriuretic peptide in umbilical cord blood: evidence for a circulating hormone in human fetus.
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脐带血中的心房钠尿肽：人类胎儿循环激素的证据。
DOI：
10.1210/jcem-63-6-1414
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
T. Nakayama
中科院分区：
文献类型：
--
作者：
T. Yamaji;N. Hirai;M. Ishibashi;F. Takaku;T. Yanaihara;T. Nakayama
为探讨心钠素（ANP）是否为胎儿体内循环激素，采用放射免疫分析法测定了10例正常新生儿分娩时脐带血中ANP水平。血浆心钠素水平一贯高于配对脐带动脉比脐带静脉样本。平均脐带动脉血浆ANP浓度[283 +/- 56（+/- SEM）pg/ml]显著高于脐带静脉血浆（165 +/- 27 pg/ml）或母体外周静脉血浆（155 +/- 25 pg/ml）。反相高效液相色谱分析表明，血浆心钠素在脐带动脉血和母体静脉血的洗脱模式几乎是相同的，主要的心钠素峰的保留时间与α-人心钠素相一致。这些结果表明α-人ANP是人胎儿中的循环激素。
To determine whether atrial natriuretic peptide (ANP) is a circulating hormone in the human fetus, ANP levels in umbilical cord plasma obtained at the time of delivery in 10 normal infants were measured by RIA. Plasma ANP levels were consistently higher in paired umbilical cord arterial than in cord venous samples. The mean umbilical cord arterial plasma ANP concentration [283 +/- 56 (+/- SEM) pg/ml] was significantly higher than that in cord venous plasma (165 +/- 27 pg/ml) or maternal peripheral venous plasma (155 +/- 25 pg/ml). Analyses by reverse phase high performance liquid chromatography revealed that the elution pattern of plasma ANP in cord arterial blood and that in maternal venous blood were nearly identical and that the retention time of the main ANP peak coincided with that of alpha-human ANP. These results suggest that alpha-human ANP is a circulating hormone in the human fetus.
健康受试者和水肿患者的免疫反应性心房钠尿因子的血浆水平。
DOI：
10.1172/jci112154
发表时间：
1985
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Shenker,Y;Sider,RS;Ostafin,EA;Grekin,RJ
通讯作者：
Grekin,RJ