Synergistic effect of a biodegradable Mg–Zn alloy on osteogenic activity and anti-biofilm ability: an in vitro and in vivo study
Synergistic effect of a biodegradable Mg–Zn alloy on osteogenic activity and anti-biofilm ability: an in vitro and in vivo study
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可生物降解的镁锌合金对成骨活性和抗生物膜能力的协同作用：体外和体内研究
DOI：
10.1039/c6ra03998g
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发表时间：
2016-05
期刊：
影响因子：
3.9
通讯作者：
Zhongmin Shi
中科院分区：
文献类型：
--
作者：
Xiaonong Zhang;Shaoxiang Zhang;Yaohua He;Zhongmin Shi
骨科种植体应同时具有良好的骨整合能力和抗生物膜能力，以预防种植体相关感染和促进骨整合。本文系统地研究了一种新型镁合金镁锌合金的抗生物膜能力和成骨活性。结果表明，Mg-Zn合金能促进大鼠骨间充质干细胞（rBMSCs）的成骨分化和基因表达，并具有比钛（Ti）更好的抗菌能力。在大鼠股骨远端模型中也观察到良好的体内抗菌能力；显微ct和组织学结果显示，尽管存在耐甲氧西林金黄色葡萄球菌（MRSA），但Mg-Zn合金在体内具有良好的骨整合性。碱性pH与镁锌合金释放的镁锌离子可能对镁锌合金的抑菌能力和成骨活性有协同作用。结果表明，即使在MRSA存在的情况下，Mg-Zn合金仍具有骨整合能力。
It is desirable for orthopaedic implants to possess good osteointegration and anti-biofilm ability simultaneously for the prevention of implant associated infections and promotion of osteointegration. In this study, both of the anti-biofilm ability and osteogenic activity of a Mg–Zn alloy as a novel magnesium alloy were investigated systematically. The in vitro findings revealed that the Mg–Zn alloy promoted osteogenic differentiation and gene expression in the rat bone mesenchymal stem cells (rBMSCs), and showed better antibacterial ability than titanium (Ti). Good antibacterial ability was also observed in vivo in a rat distal femur model; the micro-CT and histological results revealed superior osteointegration of the Mg–Zn alloy in vivo despite the presence of methicillin-resistant Staphylococcus aureus (MRSA). The alkaline pH together with magnesium and zinc ions released from the Mg–Zn alloy may have synergistic effects on the antibacterial ability and osteogenic activity of the Mg–Zn alloy. The results demonstrate that the Mg–Zn alloy possesses osteointegration ability even in the presence of MRSA.
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影响因子：
2.7
作者：
L. Helbig;H. Simank;H. Lorenz;C. Putz;C. Wölfl;A. Suda;A. Moghaddam;G. Schmidmaier;T. Guehring
通讯作者：
L. Helbig;H. Simank;H. Lorenz;C. Putz;C. Wölfl;A. Suda;A. Moghaddam;G. Schmidmaier;T. Guehring
影响因子：
4.2
作者：
Chen, Antonia F.;Schreiber, Verena M.;Evans, Andrew R.
通讯作者：
Evans, Andrew R.
影响因子：
4.1
作者：
Monfoulet, Laurent-Emmanuel;Becquart, Pierre;Logeart-Avramoglou, Delphine
通讯作者：
Logeart-Avramoglou, Delphine
影响因子：
4.9
作者：
John, Anne-Kathrin;Baldoni, Daniela;Trampuz, Andrej
通讯作者：
Trampuz, Andrej
DOI：
10.1002/jbm.10270
发表时间：
2002-11-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
Zreiqat, H;Howlett, CR;Shakibaei, M
通讯作者：
Shakibaei, M