Silencing: the establishment and inheritance of stable, repressed transcription states.
Silencing: the establishment and inheritance of stable, repressed transcription states.
复制标题
沉默:稳定的、受抑制的转录状态的建立和遗传。
DOI:
10.1016/s0959-437x(05)80286-2
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发表时间:
1992
影响因子:
4
通讯作者:
Rine,J
中科院分区:
文献类型:
--
作者:
Rivier,DH;Rine,J
Silencing refers to a particular type of transcriptional repression characterized by the formation of a genetically heritable, repressed transcriptional state. Examples of silencing include position-effect variegation, X-chromosome inactivation, and the repression of the silent mating-type gene loci in yeast. Recent discoveries suggest that silencing in yeast, like silencing in larger eukaryotes, results from a particular chromatin structure that defines a chromosomal domain. In addition, a chromosomal origin of DNA replication is required for silencing in yeast, suggesting that DNA replication plays a role in forming functional chromosomal domains.
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