Tectorial membrane travelling waves underlie abnormal hearing in Tectb mutant mice.
Tectorial membrane travelling waves underlie abnormal hearing in Tectb mutant mice.
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DOI：
10.1038/ncomms1094
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发表时间：
2010-10-19
影响因子：
16.6
通讯作者：
Freeman, Dennis M.
中科院分区：
文献类型：
--
作者：
Ghaffari, Roozbeh;Aranyosi, Alexander J.;Richardson, Guy P.;Freeman, Dennis M.
卓越的灵敏度和精致的频率选择性是哺乳动物听觉的标志，但其潜在的机制仍不清楚。降低灵敏度的耳蜗损伤和听力障碍也倾向于扩大调谐，这表明这些特性是相关的。然而，最近开发的遗传改变听力的小鼠模型（Tectb−/−）显示灵敏度降低和频率选择性更明显。在本文中，我们表明，Tectb突变减少了空间范围和传播速度的覆膜（TM）行波和这些变化的波传播可能占所有的听力异常与突变。通过减少TM波的空间范围，Tectb突变减少了激发的传播，从而增加了频率选择性。此外，TM波速度的变化减少了有效地将能量耦合到基底膜的毛细胞的数量，这降低了灵敏度。这些结果突出了TM波在听力中的重要性。 Tectb基因的突变降低了听觉灵敏度，但增加了频率选择性。在这里，作者表明，Tectb突变减少了空间和时间传播的行波沿着覆膜，解释了意想不到的听觉异常，在这个突变。
Remarkable sensitivity and exquisite frequency selectivity are hallmarks of mammalian hearing, but their underlying mechanisms remain unclear. Cochlear insults and hearing disorders that decrease sensitivity also tend to broaden tuning, suggesting that these properties are linked. However, a recently developed mouse model of genetically altered hearing (Tectb−/−) shows decreased sensitivity and sharper frequency selectivity. In this paper, we show that the Tectb mutation reduces the spatial extent and propagation velocity of tectorial membrane (TM) travelling waves and that these changes in wave propagation are likely to account for all of the hearing abnormalities associated with the mutation. By reducing the spatial extent of TM waves, the Tectb mutation decreases the spread of excitation and thereby increases frequency selectivity. Furthermore, the change in TM wave velocity reduces the number of hair cells that effectively couple energy to the basilar membrane, which reduces sensitivity. These results highlight the importance of TM waves in hearing. Mutation of the Tectb gene reduces auditory sensitivity but increases frequency selectivity. Here the authors show that Tectb mutation reduces both the spatial and temporal propagation of travelling waves along the tectorial membrane, explaining the unexpected auditory abnormalities in this mutant.
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DOI：
10.1097/moo.0b013e32830e20c4
发表时间：
2008-10
影响因子：
1.6
作者：
Richardson GP;Lukashkin AN;Russell IJ
通讯作者：
Russell IJ
影响因子：
25
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影响因子：
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作者：
KIANG, NYS;MOXON, EC
通讯作者：
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影响因子：
1.3
作者：
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通讯作者：
Freeman, DM
影响因子：
2.8
作者：
SHAH, DM;FREEMAN, DM;WEISS, TF
通讯作者：
WEISS, TF