8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier.
8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier.
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DOI：
10.1016/j.prostaglandins.2009.04.004
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发表时间：
2009-06
影响因子：
2.9
通讯作者：
Falck JR
中科院分区：
文献类型：
--
作者：
Sharma M;McCarthy ET;Reddy DS;Patel PK;Savin VJ;Medhora M;Falck JR
Glomerular dysfunction and proteinuria characterize focal segmental glomerulosclerosis (FSGS) associated with chronic kidney disease. FSGS is resistant to treatment and a circulating permeability factor (FSPF) frequently causes post-renal transplantation recurrence. In order to explore the role of 5,6-, 8,9-, 11,12- and 14,15-epoxyeicosatrienoic acids (EETs), we determined their effect on FSPF-induced increase in glomerular albumin permeability (Palb) using an in vitro assay. Exogenous 8,9-EET (1–1000nM) dose-dependently prevented the FSPF–induced increase in Palb. The other three EET regioisomers, 8,9-EET metabolite 8,9-Dihydroxyeicosatrienoic acid and unrelated 11,14-eicosadienoic acid (100 nM each) were not effective suggesting specificity of the observed glomerular protection by 8,9-EET. Synthetic analogs of 8,9-EET containing one double bond antagonized the effect of 8,9-EET on the FSPF-induced increase in Palb. Analogs containing two double bonds did not antagonize the effect of 8,9-EET and significantly blocked the FSPF-induced increase in Palb. These novel findings suggest a unique protective role for 8,9-EET in the glomerulus. Stable analogs of 8,9-EET may be valuable in developing effective management/treatment of glomerular dysfunction.
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DOI：
10.1016/0006-291x(87)90576-6
发表时间：
1987-07-31
影响因子：
3.1
作者：
CAPDEVILA, JH;KISHORE, V;FALCK, JR
通讯作者：
FALCK, JR
影响因子：
--
作者：
Garg, Puneet;Verma, Rakesh;Holzman, Lawrence B.
通讯作者：
Holzman, Lawrence B.
影响因子：
15.9
作者：
Holla, VR;Makita, K;Capdevila, JH
通讯作者：
Capdevila, JH
影响因子：
19.6
作者：
McCarthy, ET;Sharma, R;Sharma, M
通讯作者：
Sharma, M
DOI：
10.1152/ajpheart.01118.2001
发表时间：
2003-01-01
影响因子：
4.8
作者：
Medhora, M;Daniels, J;Harder, DR
通讯作者：
Harder, DR