Associations of 24 h urinary excretions of α- and γ-carboxyethyl hydroxychroman with plasma α- and γ-tocopherol and dietary vitamin E intake in older adults: the Lifelines-MINUTHE Study.
Associations of 24 h urinary excretions of α- and γ-carboxyethyl hydroxychroman with plasma α- and γ-tocopherol and dietary vitamin E intake in older adults: the Lifelines-MINUTHE Study.
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DOI：
10.1007/s00394-022-02918-8
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发表时间：
2022-10
影响因子：
5
通讯作者：
Bakker, Stephan J. L.
中科院分区：
文献类型：
--
作者：
Zhu, Yinjie;Frank, Jan;Riphagen, Ineke J.;Minovic, Isidor;Vos, Michel J.;Eggersdorfer, Manfred L.;Navis, Gerjan J.;Bakker, Stephan J. L.
维生素E的尿代谢产物，即，α-和γ-羧乙基羟基苯并二氢吡喃（α-和γ-CEHC）已受到越来越多的关注，并已被提议作为维生素E摄入和状态的新型生物标志物。然而，关于血浆α-生育酚和γ-生育酚以及膳食维生素E摄入量与α-和γ-CEHC 24 h尿排泄的关系的数据不足。本研究旨在（1）探讨尿α-和γ-CEHC/肌酐比值及24 h尿α-和γ-CEHC排泄量与血浆α-和γ-生育酚的关系;（2）探讨尿α-和γ-CEHC/肌酐比值及24 h尿α-和γ-CEHC排泄量与膳食维生素E摄入量的关系，我们假设24 h尿α-和γ-CEHC排泄与维生素E摄入量的相关性比尿α-和γ-CEHC/肌酐比值更好。从纳入Lifelines-CENTHE研究的1519例受试者（60-75岁，男性：50%）中采集24 h尿液和血浆样本，用于评估尿液α-和γ-CEHC/肌酐比值以及α-和γ-CEHC的24 h尿液排泄和血浆α-和γ-生育酚。在这些参与者中，来自387名参与者的膳食维生素E摄入量数据来自外部验证的花卉食物频率问卷（FFQ）。采用多元线性回归分析评估血浆α-和γ-生育酚、膳食维生素E摄入量与尿α-和γ-CEHC的相关性。24小时α-CEHC的尿排泄量（中位数（IQR）：0.9（0.3-2.4）µmol）低于γ-CEHC（中位数（IQR）：1.5（0.5-3.5）µmol）。校正协变量后，我们发现24小时尿α-CEHC排泄量和尿α-CEHC/肌酐比值均与血浆α-生育酚呈正相关（标准品β：0.06，p = 0.02;标准品β：0.06，p = 0.01）。此外，24 h尿α-和γ-CEHC排泄量总和与膳食维生素E摄入量呈正相关（标准β：0.08; p = 0.03），而尿α-和γ-CEHC/肌酐比值与维生素E摄入量之间无相关性。血浆α-和γ-生育酚与膳食维生素E摄入量之间以及尿γ-CEHC与血浆γ-生育酚之间均未观察到相关性。我们的研究证实了我们的假设，即24 h尿α-和γ-CEHC排泄比尿α-和γ-CEHC/肌酐比值更能反映膳食维生素E摄入量。考虑到24 h尿α-和γ-CEHC排泄以及α-和γ-CEHC/肌酐比值也与血浆α-生育酚状态相关，我们建议24 h尿α-和γ-CEHC排泄可用于评估总体维生素E状态。在线版本包含补充材料，可通过10.1007/s 00394 -022-02918-8获得。
Urinary metabolites of vitamin E, i.e., α- and γ-carboxyethyl hydroxychroman (α- and γ-CEHC), have gained increasing attention and have been proposed as novel biomarkers of vitamin E intake and status. However, there are insufficient data on the relationship of plasma α-tocopherol and γ-tocopherol and dietary vitamin E intake with 24 h urinary excretions of α- and γ-CEHC. We aimed to (1) investigate the associations of urinary α- and γ-CEHC/creatinine ratios and 24 h urinary excretions of α- and γ-CEHC with plasma α- and γ-tocopherol, respectively; (2) investigate the associations of urinary α- and γ-CEHC/creatinine ratios and 24 h urinary excretions of α- and γ-CEHC with dietary vitamin E intake, and we hypothesize that 24 h urinary excretions of α- and γ-CEHC will better correlate with vitamin E intake than urinary α- and γ-CEHC/creatinine ratios. 24 h Urine and plasma samples were collected from 1519 participants (60–75 years, male: 50%) included in the Lifelines-MINUTHE Study for the assessments of urinary α- and γ-CEHC/creatinine ratios and 24 h urinary excretions of α- and γ-CEHC, and plasma α- and γ-tocopherol. Among those participants, dietary vitamin E intake data from 387 participants were available from an externally validated Flower-Food Frequency Questionnaire (FFQ). The associations of plasma α- and γ-tocopherol, dietary vitamin E intake, with urinary α- and γ-CEHC were assessed using multivariate linear regressions. 24 h Urinary excretion of α-CEHC (median (IQR): 0.9 (0.3–2.4) µmol) was less than that of γ-CEHC (median (IQR): 1.5 (0.5–3.5) µmol). After adjustment for covariates, we found that 24 h urinary α-CEHC excretion and urinary α-CEHC/creatinine ratio were both positively associated with plasma α-tocopherol (std.beta: 0.06, p = 0.02; std.beta: 0.06, p = 0.01, respectively). Furthermore, the sum of 24 h urinary α- and γ-CEHC excretions was positively associated with dietary vitamin E intake (std.beta: 0.08; p = 0.03), whereas there was no relation between urinary α- and γ-CEHC/creatinine ratios and vitamin E intake. No association was observed neither between plasma α- and γ-tocopherol and dietary vitamin E intake, nor between urinary γ-CEHC and plasma γ-tocopherol. Our study confirmed our hypothesis that 24 h urinary α- and γ-CEHC excretions would be a better marker for dietary vitamin E intake than urinary α- and γ-CEHC/creatinine ratios. Considering that both 24 h urinary α- and γ-CEHC excretions and α- and γ-CEHC/creatinine ratios were also associated with plasma α-tocopherol status, we suggest that 24 h urinary α- and γ-CEHC excretions could be used to assess overall vitamin E status. The online version contains supplementary material available at 10.1007/s00394-022-02918-8.
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DOI：
10.1056/nejmoa0907929
发表时间：
2010-05-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Sanyal AJ;Chalasani N;Kowdley KV;McCullough A;Diehl AM;Bass NM;Neuschwander-Tetri BA;Lavine JE;Tonascia J;Unalp A;Van Natta M;Clark J;Brunt EM;Kleiner DE;Hoofnagle JH;Robuck PR;NASH CRN
通讯作者：
NASH CRN
影响因子：
3.3
作者：
Agostoni, Carlo;Canani, Roberto Berni;Verhagen, Hans
通讯作者：
Verhagen, Hans
影响因子：
11.4
作者：
Podszun MC;Frank J
通讯作者：
Frank J
DOI：
10.1016/j.bbrc.2017.03.065
发表时间：
2017-04-29
影响因子：
3.1
作者：
Kamishikiryo, Jun;Haraguchi, Misaki;Morita, Tetsuo
通讯作者：
Morita, Tetsuo
影响因子：
7.7
作者：
Scholtens, Salome;Smidt, Nynke;Stolk, Ronald P.
通讯作者：
Stolk, Ronald P.