Receptor Signaling Directs Global Recruitment of Pre-existing Transcription Factors to Inducible Elements
Receptor Signaling Directs Global Recruitment of Pre-existing Transcription Factors to Inducible Elements
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受体信号传导引导预先存在的转录因子向诱导元件的全球招募
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
P. Cockerill
中科院分区：
文献类型：
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作者：
P. Cockerill
基因表达程序很大程度上受谱系定义转录因子的组织特异性表达或响应于特定刺激的转录因子的诱导表达的调节。在这里，我将回顾我们过去 20 年的工作，以展示特定的激活信号如何导致预先存在的组成型转录因子广泛地重新分布到正在进行染色质重组的位点。我将总结研究，这些研究表明激酶信号通路的激活会创建开放的染色质区域，这些区域会招募先前无法与封闭染色质结合的预先存在的因子。作为模型，我将利用记忆 T 细胞中由受体信号传导激活或引发的基因，以及急性髓系白血病中由细胞因子受体突变激活的基因。我还总结了记忆 T 细胞中稳定表观遗传重编程的“打了就跑”模型，该模型由瞬时激活蛋白 1 (AP-1) 结合介导，可加速诱导增强子的激活。
Gene expression programs are largely regulated by the tissue-specific expression of lineage-defining transcription factors or by the inducible expression of transcription factors in response to specific stimuli. Here I will review our own work over the last 20 years to show how specific activation signals also lead to the wide-spread re-distribution of pre-existing constitutive transcription factors to sites undergoing chromatin reorganization. I will summarize studies showing that activation of kinase signaling pathways creates open chromatin regions that recruit pre-existing factors which were previously unable to bind to closed chromatin. As models I will draw upon genes activated or primed by receptor signaling in memory T cells, and genes activated by cytokine receptor mutations in acute myeloid leukemia. I also summarize a hit-and-run model of stable epigenetic reprograming in memory T cells, mediated by transient Activator Protein 1 (AP-1) binding, which enables the accelerated activation of inducible enhancers.
表观遗传记忆对免疫记忆的贡献。
影响因子：
4
作者：
Zediak,ValerieP;Wherry,EJohn;Berger,ShelleyL
通讯作者：
Berger,ShelleyL
影响因子：
16
作者：
Cirillo, LA;Lin, FR;Zaret, KS
通讯作者：
Zaret, KS