BTLA, a key regulator of Vγ9Vδ2 T-cell proliferation.

BTLA, a key regulator of Vγ9Vδ2 T-cell proliferation.
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DOI:
10.4161/onci.25853
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发表时间:
2013-09-01
期刊:
影响因子:
7.2
通讯作者:
Olive D
Olive D
中科院分区:
医学2区
文献类型:
--
作者:
Gertner-Dardenne J;Fauriat C;Olive D

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尽管在过去的几年中,γδ T淋巴细胞作为潜在的抗癌免疫治疗剂已经成为越来越受关注的主题,但这些细胞的增殖和效应反应如何调节仍然不清楚。我们最近报道了共受体B和T淋巴细胞相关(BTLA)抑制人Vγ 9 V δ2 T细胞的增殖,潜在地支持淋巴瘤细胞的免疫逃逸机制。
Although in the last few years γδ T lymphocytes have been the subject of growing interest as potential anticancer immunotherapeutics, how the proliferative and effector responses of these cells are regulated remains unclear. We have recently reported that the co-receptor B and T lymphocyte associated (BTLA) inhibits the proliferation of human Vγ9Vδ2 T cells, potentially underpinning a mechanism of immune escape by lymphoma cells.
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