BTLA, a key regulator of Vγ9Vδ2 T-cell proliferation.
BTLA, a key regulator of Vγ9Vδ2 T-cell proliferation.
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DOI:
10.4161/onci.25853
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发表时间:
2013-09-01
期刊:
影响因子:
7.2
通讯作者:
Olive D
中科院分区:
文献类型:
--
作者:
Gertner-Dardenne J;Fauriat C;Olive D
Although in the last few years γδ T lymphocytes have been the subject of growing interest as potential anticancer immunotherapeutics, how the proliferative and effector responses of these cells are regulated remains unclear. We have recently reported that the co-receptor B and T lymphocyte associated (BTLA) inhibits the proliferation of human Vγ9Vδ2 T cells, potentially underpinning a mechanism of immune escape by lymphoma cells.
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