Farnesoid X Receptor Constructs an Immunosuppressive Microenvironment and Sensitizes FXRhighPD-L1low NSCLC to Anti–PD-1 Immunotherapy

Farnesoid X Receptor Constructs an Immunosuppressive Microenvironment and Sensitizes FXRhighPD-L1low NSCLC to Anti–PD-1 Immunotherapy
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Farnesoid X 受体构建免疫抑制微环境并使 FXRhighPD-L1low NSCLC 对抗 PD-1 免疫疗法敏感

DOI:
10.1158/2326-6066.cir-17-0672
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发表时间:
2019-04
影响因子:
10.1
通讯作者:
ong Jiang
ong Jiang
中科院分区:
医学1区
文献类型:
--
作者:
Wenjie You;Lijun Li;Deqiao Sun;Xueqing Liu;Zongjun Xia;Shan Xue;Bi Chen;Hui Qin;Jing Ai;H;ong Jiang

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A subtype of non-small cell lung cancer is characterized by immunosuppression through the farnesoid X receptor (FXR) and responsiveness to anti–PD-1 therapy. The combination of high FXR expression and low PD-L1 expression may identify patients receptive t
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