Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle.
Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle.
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DOI：
10.1016/j.bbadis.2013.03.011
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发表时间：
2013-09
影响因子：
6.2
通讯作者：
Brown-Borg, Holly M.
中科院分区：
文献类型：
--
作者：
Romanick, Mark;Thompson, LaDora V.;Brown-Borg, Holly M.
With the extension of life span over the past several decades, the age-related loss of muscle mass and strength that characterizes sarcopenia is becoming more evident and thus, has a more significant impact on society. To determine ways to intervene and delay, or even arrest the physical frailty and dependence that accompany sarcopenia, it is necessary to identify those biochemical pathways that define this process. Animal models that mimic one or more of the physiological pathways involved with this phenomenon are very beneficial in providing an understanding of the cellular processes at work in sarcopenia. The ability to influence pathways through genetic manipulation gives insight into cellular responses and their impact on the physical expression of sarcopenia. This review evaluates several murine models that have the potential to elucidate biochemical processes integral to sarcopenia. Identifying animal models that reflect sarcopenia or its component pathways will enable researchers to better understand those pathways that contribute to age-related skeletal muscle mass loss, and in turn, develop interventions that will prevent, retard, arrest, or reverse this phenomenon.
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影响因子：
4.8
作者：
Amirouche, Adel;Durieux, Anne-Cecile;Freyssenet, Damien
通讯作者：
Freyssenet, Damien
影响因子：
4.1
作者：
Brown-Borg HM
通讯作者：
Brown-Borg HM
影响因子：
5.5
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通讯作者：
Unterman, Terry G.
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10.5
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Chen, WS;Xu, PZ;Hay, N
通讯作者：
Hay, N
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5.3
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Bar-Shai, M;Carmeli, E;Reznick, AZ
通讯作者：
Reznick, AZ