Stem cell homing in musculoskeletal injury.
Stem cell homing in musculoskeletal injury.
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DOI：
10.1016/j.biomaterials.2010.08.101
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发表时间：
2011-01
期刊：
影响因子：
14
通讯作者：
Goodman, Stuart B.
中科院分区：
文献类型：
--
作者：
Fong, Eliza L. S.;Chan, Casey K.;Goodman, Stuart B.
损伤的成年组织的再生潜力表明能够参与修复过程的细胞的生理存在。最近的研究表明，驻留在组织中的干细胞样细胞有助于组织修复，并由前体骨髓来源的细胞补充。间充质基质细胞（MSC）是修复细胞的候选者之一。这些细胞可以响应损伤信号被动员到循环中，并在损伤部位发挥其修复作用。目前用于肌肉骨骼损伤的治疗方法存在不可避免的风险，可能会阻碍完全康复。MSC向损伤部位的运输及其随后参与再生过程被认为是一种自然愈合反应，其可以通过用外源性施用的MSC增强内源性MSC库来模仿或增强。因此，一个有前途的替代现有的战略中采用的治疗肌肉骨骼损伤是加强固有的修复能力的身体提供MSC收获从患者自身组织的损伤部位。这篇评论的目的是告知读者的研究已经评估了内在的归巢和再生能力的MSC，特别强调肌肉骨骼损伤的修复。支持直接使用MSC的研究（不需要体外分化为组织特异性细胞）也将被报道。基于越来越多的证据表明，自然愈合机制涉及MSC的招募及其随后在损伤部位的修复作用，以及MSC外源性给药后记录的治疗反应，将提出即时干细胞治疗的新兴策略的可行性。
The regenerative potential of injured adult tissue suggests the physiological existence of cells capable of participating in the reparative process. Recent studies indicate that stem-like cells residing in tissues contribute to tissue repair and are replenished by precursor bone marrow–derived cells. Mesenchymal stromal cells (MSC) are among the candidates for reparative cells. These cells can potentially be mobilized into the circulation in response to injury signals and exert their reparative effects at the site of injury. Current therapies for musculoskeletal injuries pose unavoidable risks which can impede full recovery. Trafficking of MSC to the injury site and their subsequent participation in the regenerative process is thought to be a natural healing response that can be imitated or augmented by enhancing the endogenous MSC pool with exogenously administered MSC. Therefore, a promising alternative to the existing strategies employed in the treatment of musculoskeletal injuries is to reinforce the inherent reparative capacity of the body by delivering MSC harvested from the patient’s own tissues to the site of injury. The aim of this review is to inform the reader of studies that have evaluated the intrinsic homing and regenerative abilities of MSC, with particular emphasis on the repair of musculoskeletal injuries. Research that supports the direct use of MSC (without in vitro differentiation into tissue-specific cells) will also be reported. Based on accruing evidence that the natural healing mechanism involves the recruitment of MSC and their subsequent reparative actions at the site of injury, as well as documented therapeutic response after the exogenous administration of MSC, the feasibility of the emerging strategy of instant stem-cell therapy will be proposed.
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DOI：
10.1007/s004290050237
发表时间：
1999-05-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
Bittner, RE;Schöfer, C;Wachtler, F
通讯作者：
Wachtler, F
影响因子：
5.3
作者：
Cuomo, Anna V.;Virk, Mandeep;Lieberman, Jay R.
通讯作者：
Lieberman, Jay R.
影响因子：
--
作者：
Chen, Wei-Hong;Lai, Ming-Tang;Deng, Win-Ping
通讯作者：
Deng, Win-Ping
影响因子：
3.5
作者：
Chapel, A;Bertho, JM;Thierry, D
通讯作者：
Thierry, D
影响因子：
4.4
作者：
Chen, JL;Li, Y;Chopp, M
通讯作者：
Chopp, M