Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders.
Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders.
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DOI：
10.3389/fnins.2015.00198
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发表时间：
2015
影响因子：
4.3
通讯作者：
Claus P
中科院分区：
文献类型：
--
作者：
Hensel N;Rademacher S;Claus P
近年来，ROCK抑制已被广泛应用于神经退行性疾病（NDD）的治疗，并取得了可喜的成果。然而，潜在的分子和细胞机制尚未完全理解，并且已经提出了用于神经退行性疾病的不同模型。在这里，我们的目的是审查目前的知识获得的NDD确定共同的机制，以及疾病特异性模型。除了ROCK在不同细胞类型如神经元和小胶质细胞中的作用外，我们还关注介导ROCK有益作用的分子信号通路。除了典型的ROCK信号传导之外，通过非典型的ROCK-串扰对相邻通路的调节是许多NDD模型系统中的复发模式，并且已经被建议介导ROCK抑制的有益效果。
ROCK inhibition has been largely applied as a strategy to treat neurodegenerative diseases (NDDs) and promising results have been obtained in the recent years. However, the underlying molecular and cellular mechanisms are not fully understood and different models have been proposed for neurodegenerative disorders. Here, we aim to review the current knowledge obtained for NDDs identifying common mechanisms as well as disease-specific models. In addition to the role of ROCK in different cell types such as neurons and microglia, we focus on the molecular signaling-pathways which mediate the beneficial effects of ROCK. Besides canonical ROCK signaling, modulation of neighboring pathways by non-canonical ROCK-crosstalk is a recurrent pattern in many NDD-model systems and has been suggested to mediate beneficial effects of ROCK-inhibition.
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影响因子：
4.4
作者：
Gurney, ME
通讯作者：
Gurney, ME
影响因子：
3.7
作者：
Deyts C;Galan-Rodriguez B;Martin E;Bouveyron N;Roze E;Charvin D;Caboche J;Bétuing S
通讯作者：
Bétuing S
影响因子：
15.1
作者：
Bauer PO;Hudec R;Goswami A;Kurosawa M;Matsumoto G;Mikoshiba K;Nukina N
通讯作者：
Nukina N
影响因子：
2.5
作者：
Duffy SS;Lees JG;Moalem-Taylor G
通讯作者：
Moalem-Taylor G
影响因子：
4.8
作者：
Hensel, Niko;Stockbruegger, Inga;Claus, Peter
通讯作者：
Claus, Peter