Role of Mitochondria in Podocyte Injury
Role of Mitochondria in Podocyte Injury
复制标题
线粒体在足细胞损伤中的作用
DOI：
10.1159/000359929
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发表时间：
2014-05
影响因子：
--
通讯作者：
Zhang, Aihua
中科院分区：
文献类型：
--
作者：
Yuan, Yanggang;Huang, Songming;Zhang, Aihua
线粒体是细胞器，通过合成三磷酸腺苷 (ATP) 产生细胞过程所需的能量。它们还有助于广泛的细胞功能，包括活性氧 (ROS) 的产生、钙稳态和诱导细胞凋亡。线粒体也含有自己的 DNA，称为线粒体 DNA (mtDNA)。通过这些不同的作用，线粒体在遗传、生长、代谢以及疾病的发生和进展中发挥着重要作用。足细胞是肾脏高度特化的上皮细胞。足细胞损伤被认为是多种肾小球疾病发生的关键因素。在重点讨论足细胞损伤中的线粒体功能障碍之前，先介绍线粒体的结构和功能。以局灶节段性肾小球硬化症作为核编码线粒体疾病的例子，讨论了线粒体 DNA 的变化。然后检查足细胞中 ATP 的合成；由于肾脏消耗大量能量，任何供应中断都可能导致肾功能障碍。还讨论了线粒体 ROS 产生和钙紊乱，以及线粒体自噬和线粒体动力学。最后，概述了了解与线粒体功能障碍和足细胞损伤有关的生物过程所面临的众多挑战，以制定改善人类健康的策略。
Mitochondria are cellular organelles that produce the energy required for cellular processes through synthesis of adenosine triphosphate (ATP). They also contribute to a wide range of cellular functions, including reactive oxygen species (ROS) generation, calcium homeostasis, and induction of apoptosis. Mitochondria also contain their own DNA, known as mitochondrial DNA (mtDNA). Through these varied roles, mitochondria are important in heredity, growth, metabolism, and the occurrence and progression of diseases. Podocytes are highly specialized epithelial cells of the kidney. Podocyte injury is considered a key factor in the development of many forms of glomerular disease. A description of the structure and functions of mitochondria is provided, before focusing on mitochondrial dysfunction in podocyte injury. Changes in mtDNA are discussed, using focal segmental glomerulosclerosis as an example of a nuclear-encoded mitochondrial disease. ATP synthesis in podocytes is then examined; as the kidney consumes a large amount of energy, any disruption in supply is likely to cause renal dysfunction. Mitochondrial ROS production and calcium disorders, and mitophagy and mitochondrial dynamics are also discussed. Finally, an outline of the numerous challenges in understanding the biological processes involved with mitochondrial dysfunction and podocyte injury required to develop strategies for improving human health is provided.
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影响因子：
7.4
作者：
Dikalov, Sergey
通讯作者：
Dikalov, Sergey
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影响因子：
4.5
作者：
Peng, Min;Falk, Marni J.;Haase, Volker H.;King, Rhonda;Polyak, Erzsebet;Selak, Mary;Yudkoff, Marc;Hancock, Wayne W.;Meade, Ray;Saiki, Ryoichi;Lunceford, Adam L.;Clarke, Catherine F.;Gasser, David L.
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Gasser, David L.
影响因子：
18.2
作者：
Greka A;Mundel P
通讯作者：
Mundel P
DOI：
10.1073/pnas.0511154103
发表时间：
2006-02-21
影响因子：
11.1
作者：
Yu, TZ;Robotham, JL;Yoon, Y
通讯作者：
Yoon, Y
影响因子：
13.6
作者：
Nakajo, Aya;Khoshnoodi, Jamshid;Yan, Kunimasa
通讯作者：
Yan, Kunimasa