The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives.
The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives.
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DOI：
10.1039/c7cc07549a
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发表时间：
2018-01-31
期刊：
影响因子：
--
通讯作者：
Rompel A
中科院分区：
文献类型：
--
作者：
Bijelic A ;Aureliano M ;Rompel A
这篇专题文章重点介绍了POM的抗菌活性以及基于POM的杂化和纳米复合结构，重点介绍了生物活性POM系统合成的最新进展，并提供了该研究领域的最新技术水平。聚氧乙烯酸盐（POM）主要是阴离子金属氧化物化合物，其跨越广泛的可调物理和化学特征，使得它们对于生物学目的非常有趣，这是一个不断出现但很少探索的领域。由于其生物和生化效应，包括抗肿瘤，抗病毒和抗细菌的特性，POM和POM为基础的系统被认为是有前途的未来金属药物。在这篇文章中，我们重点介绍了多金属氧酸盐的抗菌活性及其在对抗细菌和增加对药物的耐药性方面的治疗潜力。在POM的合成的最新进展突出，重点是生物活性POM为基础的混合和纳米复合结构的发展和性能。通过对多酸酯抗菌活性和结构的分析，提出了多酸酯与蛋白质相互作用的可能靶点，并建立了一系列多酸酯对幽门螺杆菌和肺炎链球菌的结构-活性关系。
This Feature Article focuses on the antibacterial activity of POMs and POM-based hybrid and nanocomposite structures highlighting recent advances in the synthesis of biologically active POM systems and providing the state of the art in this research field. Polyoxometalates (POMs) are, mostly anionic, metal oxide compounds that span a wide range of tunable physical and chemical features rendering them very interesting for biological purposes, an continuously emerging but little explored field. Due to their biological and biochemical effects, including antitumor, -viral and -bacterial properties, POMs and POM-based systems are considered as promising future metallodrugs. In this article, we focus on the antibacterial activity of POMs and their therapeutic potential in the battle against bacteria and their increasing resistance against pharmaceuticals. Recent advances in the synthesis of POMs are highlighted, with emphasis on the development and properties of biologically active POM-based hybrid and nanocomposite structures. By analysing the antibacterial activity and structure of POMs, putative mode of actions are provided, including potential targets for POM–protein interactions, and a structure–activity-relationship was established for a series of POMs against two bacteria, namely Helicobacter pylori and Streptococcus pneumoniae.
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DOI：
10.1002/chem.201502458
发表时间：
2015-12-01
期刊：
Chemistry (Weinheim an der Bergstrasse, Germany)
影响因子：
--
作者：
Al-Sayed E;Blazevic A;Roller A;Rompel A
通讯作者：
Rompel A
影响因子：
4.3
作者：
Blazevic, Amir;Al-Sayed, Emir;Rompel, Annette
通讯作者：
Rompel, Annette
影响因子：
3.7
作者：
Daima HK;Selvakannan PR;Shukla R;Bhargava SK;Bansal V
通讯作者：
Bansal V
影响因子：
18.3
作者：
Bijelic A;Rompel A
通讯作者：
Rompel A
DOI：
10.1007/s00244-003-2155-1
发表时间：
2003-10-01
影响因子：
4
作者：
Borges, G;Mendonça, P;Aureliano, M
通讯作者：
Aureliano, M