Fine-tuning the antimicrobial profile of biocompatible gold nanoparticles by sequential surface functionalization using polyoxometalates and lysine.
Fine-tuning the antimicrobial profile of biocompatible gold nanoparticles by sequential surface functionalization using polyoxometalates and lysine.
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DOI：
10.1371/journal.pone.0079676
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Bansal V
中科院分区：
文献类型：
--
作者：
Daima HK;Selvakannan PR;Shukla R;Bhargava SK;Bansal V
纳米材料的抗菌作用通常与纳米材料的组成、尺寸和/或形状有关，而稳定纳米颗粒表面的复合电晕的影响往往被忽视。我们展示了酪氨酸还原金纳米颗粒（AuNPsTyr）与多金属氧酸盐（POMs）和赖氨酸的连续表面功能化，以探索受控的化学功能驱动的抗菌活性。我们的研究表明，高度生物相容性的金纳米颗粒可以通过以可控的方式微调其表面特性而成为一种强抗菌剂。通过研究这些阶梯表面控制材料对A549人肺癌细胞的抗癌特性，进一步验证了对革兰氏阴性细菌大肠杆菌的抗菌研究结果，显示出相似的毒性模式。这些研究强调了纳米材料的毒性和生物学适用性在很大程度上取决于它们的表面电晕。
Antimicrobial action of nanomaterials is typically assigned to the nanomaterial composition, size and/or shape, whereas influence of complex corona stabilizing the nanoparticle surface is often neglected. We demonstrate sequential surface functionalization of tyrosine-reduced gold nanoparticles (AuNPsTyr) with polyoxometalates (POMs) and lysine to explore controlled chemical functionality-driven antimicrobial activity. Our investigations reveal that highly biocompatible gold nanoparticles can be tuned to be a strong antibacterial agent by fine-tuning their surface properties in a controllable manner. The observation from the antimicrobial studies on a gram negative bacterium Escherichia coli were further validated by investigating the anticancer properties of these step-wise surface-controlled materials against A549 human lung carcinoma cells, which showed a similar toxicity pattern. These studies highlight that the nanomaterial toxicity and biological applicability are strongly governed by their surface corona.
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