Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
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DOI：
10.1038/ng.3685
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发表时间：
2016-12
期刊：
影响因子：
30.8
通讯作者：
Brennan, Paul
中科院分区：
文献类型：
--
作者：
Lesseur, Corina;Diergaarde, Brenda;Olshan, Andrew F.;Wunsch-Filho, Victor;Ness, Andrew R.;Liu, Geoffrey;Lacko, Martin;Eluf-Neto, Jose;Franceschi, Silvia;Lagiou, Pagona;Macfarlane, Gary J.;Richiardi, Lorenzo;Boccia, Stefania;Polesel, Jerry;Kjaerheim, Kristina;Zaridze, David;Johanson, Mattias;Menezes, Ana M.;Curado, Maria Paula;Robinson, Max;Ahrens, Wolfgang;Canova, Cristina;Znaor, Ariana;Castellsague, Xavier;Conway, David I.;Holcatova, Ivana;Mates, Dana;Vidensky, Marta;Healy, Claire M.;Szeszenia-Dbrowska, Neonila;Fabianova, Eleonora;Lissowska, Jolanta;Grandis, Jennifer R.;Weissler, Mark C.;Tajara, Eloiza H.;Nunes, Fabio D.;de Carvalho, Marcos B.;Thomas, Steve;Hung, Rayjean J.;Peters, Wilbert H. M.;Herrero, Rolando;Cadoni, Gabriella;Bueno-de-Mesquita, H. Bas;Steffen, Annika;Agudo, Antonio;Shangina, Oxana;Xiao, Xiangjun;Gaborieau, Valerie;Chabrier, Amelie;Anantharaman, Devasena;Boffetta, Paolo;Amos, Christopher I.;Mckay, James D.;Brennan, Paul
我们对来自欧洲、北美和南美的6，034例病例和6，585例对照进行了口腔和咽癌的全基因组关联研究;我们检测到8个位点（P<5x 10 -8），其中7个是这些癌症部位的新位点。口腔癌和咽癌合并与6p21.32（rs3828805，HLA-DQB 1），10q26.13（rs 201982221，LHPP）和11p15.4（rs 1453414，OR 52 N2/TRIM 5）位点相关。口腔癌与两个新区域2p23.3（rs6547741，GPN 1）和9q34.12（rs 928674，LAMC 3）相关，并与已知的癌症基因座：9p21.3（rs 8181047，CDKN 2B-AS 1）和5p15.33（rs 10462706，CLPTM 1 L）相关。口咽癌的相关性仅限于人类白细胞抗原（HLA）区域，经典的HLA等位基因插补显示与II类单倍型DRB 1 *1301-DQA 1 *0103-DQB 1 *0603有保护性关联（比值比（OR）=0.59，P=2.7x10-9）。对人乳头状瘤病毒（HPV）状态的口咽病例亚组的分层分析表明，与HPV阴性癌症（OR=0.75，P=0.16）相比，HPV阳性癌症（OR=0.23，P=1.6x10-6）的这种相关性更强。
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America; we detected 8 loci (P<5x10–8), 7 of which are novel for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2/TRIM5). Oral cancer was associated with two new regions 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer loci: 9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region and classical HLA allele imputation revealed a protective association with the class II haplotype DRB1*1301-DQA1*0103-DQB1*0603 (odds ratio (OR)=0.59, P=2.7x10–9). Stratified analyses on a subgroup of oropharyngeal cases with human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR=0.23, P=1.6x10–6) compared to HPV-negative cancers (OR=0.75, P=0.16).
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影响因子：
30.8
作者：
Shete S;Hosking FJ;Robertson LB;Dobbins SE;Sanson M;Malmer B;Simon M;Marie Y;Boisselier B;Delattre JY;Hoang-Xuan K;El Hallani S;Idbaih A;Zelenika D;Andersson U;Henriksson R;Bergenheim AT;Feychting M;Lönn S;Ahlbom A;Schramm J;Linnebank M;Hemminki K;Kumar R;Hepworth SJ;Price A;Armstrong G;Liu Y;Gu X;Yu R;Lau C;Schoemaker M;Muir K;Swerdlow A;Lathrop M;Bondy M;Houlston RS
通讯作者：
Houlston RS
影响因子：
30.8
作者：
McKay, James D.;Hung, Rayjean J.;Gaborieau, Valerie;Boffetta, Paolo;Chabrier, Amelie;Byrnes, Graham;Zaridze, David;Mukeria, Anush;Szeszenia-Dabrowska, Neonilia;Lissowska, Jolanta;Rudnai, Peter;Fabianova, Eleonora;Mates, Dana;Bencko, Vladimir;Foretova, Lenka;Janout, Vladimir;McLaughlin, John;Shepherd, Frances;Montpetit, Alexandre;Narod, Steven;Krokan, Hans E.;Skorpen, Frank;Elvestad, Maiken Bratt;Vatten, Lars;Njolstad, Inger;Axelsson, Tomas;Chen, Chu;Goodman, Gary;Barnett, Matt;Loomis, Melissa M.;Lubinski, Jan;Matyjasik, Joanna;Lener, Marcin;Oszutowska, Dorota;Field, John;Liloglou, Triantafillos;Xinarianos, George;Cassidy, Adrian;Zelenika, Diana;Boland, Anne;Delepine, Marc;Foglio, Mario;Lechner, Doris;Matsuda, Fumihiko;Blanche, Helene;Gut, Ivo;Heath, Simon;Lathrop, Mark;Brennan, Paul
通讯作者：
Brennan, Paul
影响因子：
30.8
作者：
Bei, Jin-Xin;Li, Yi;Zeng, Yi-Xin
通讯作者：
Zeng, Yi-Xin
影响因子：
30.8
作者：
Hashibe, Mia;Mckay, James D.;Brennan, Paul
通讯作者：
Brennan, Paul
影响因子：
25
作者：
Ramasamy, Adaikalavan;Trabzuni, Daniah;Guelfi, Sebastian;Varghese, Vibin;Smith, Colin;Walker, Robert;De, Tisham;Coin, Lachlan;de Silva, Rohan;Cookson, Mark R.;Singleton, Andrew B.;Hardy, John;Ryten, Mina;Weale, Michael E.
通讯作者：
Weale, Michael E.