Evaluation of the electric field in the brain during transcranial direct current stimulation: A sensitivity analysis
Evaluation of the electric field in the brain during transcranial direct current stimulation: A sensitivity analysis
复制标题
经颅直流电刺激期间大脑电场的评估：敏感性分析
DOI：
10.1109/embc.2016.7591062
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
P. Miranda
中科院分区：
文献类型：
--
作者：
L. Santos;M. Martinho;R. Salvador;C. Wenger;S. Fernandes;O. Ripolles;G. Ruffini;P. Miranda
计算建模研究的使用是目前预测经颅直流电刺激中电场（E场）分布的最佳方法。与任何模型一样，归因于物理性质的值，即组织的电导率，影响预测的电场分布。文献中报道了大多数组织的电导率的广泛值。在这项工作中，我们使用有限元方法来计算在一个现实的人的头部模型中，针对左背外侧前额叶皮层（DLPFC）的两个电极蒙太奇诱导的电场。针对标准双极7×5 cm 2电极配置和优化的多电极导联，对不同各向同性电导率分布对电场分布的影响进行了系统分析。计算左侧DLPFC靶区的电场幅度、法向和切向分量的平均值。结果表明，随着头皮、脑脊液（CSF）和灰质（GM）电导率的增加，场减小，而颅骨和白色物质的电导率则相反。导电性对皮层中的电场影响最大的组织是头皮和CSF，其次是GM和颅骨。单个组织的电导率的不稳定可能影响电场值高达约80%。
The use of computational modeling studies accounts currently for the best approach to predict the electric field (E-field) distribution in transcranial direct current stimulation. As with any model, the values attributed to the physical properties, namely the electrical conductivity of the tissues, affect the predicted E-field distribution. A wide range of values for the conductivity of most tissues is reported in the literature. In this work, we used the finite element method to compute the E-field induced in a realistic human head model for two electrode montages targeting the left dorso-lateral prefrontal cortex (DLPFC). A systematic analysis of the effect of different isotropic conductivity profiles on the E-field distribution was performed for the standard bipolar 7×5 cm2 electrodes configuration and also for an optimized multielectrode montage. Average values of the E-field's magnitude, normal and tangential components were calculated in the target region in the left DLPFC. Results show that the field decreases with increasing scalp, cerebrospinal fluid (CSF) and grey matter (GM) conductivities, while the opposite is observed for the skull and white matter conductivities. The tissues whose conductivity most affects the E-field in the cortex are the scalp and the CSF, followed by the GM and the skull. Uncertainties in the conductivity of individual tissues may affect electric field values by up to about 80%.
影响因子：
--
作者：
George, Mark S.;Lisanby, Sarah H.;Sackeim, Harold A.
通讯作者：
Sackeim, Harold A.
影响因子：
4
作者：
Schmidt C;Wagner S;Burger M;Rienen Uv;Wolters CH
通讯作者：
Wolters CH
在高度逼真的头部模型中研究 tDCS 体积传导效应
影响因子：
4
作者：
Wagner S;Rampersad SM;Aydin Ü;Vorwerk J;Oostendorp TF;Neuling T;Herrmann CS;Stegeman DF;Wolters CH
通讯作者：
Wolters CH