Investigation of tDCS volume conduction effects in a highly realistic head model
Investigation of tDCS volume conduction effects in a highly realistic head model
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在高度逼真的头部模型中研究 tDCS 体积传导效应
DOI：
10.1088/1741-2560/11/1/016002
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发表时间：
2014
影响因子：
4
通讯作者：
Wolters CH
中科院分区：
文献类型：
--
作者：
Wagner S;Rampersad SM;Aydin Ü;Vorwerk J;Oostendorp TF;Neuling T;Herrmann CS;Stegeman DF;Wolters CH
我们研究了经颅直流电刺激（tDCS）中的体积传导效应，并提出了一个指导方针，有效而准确的体积导体建模在tDCS中使用我们新开发的有限元（FE）approach.ApproachWe开发了一种新的，准确和快速的等参数有限元方法，用于高分辨率的几何形状适应六面体网格和组织各向异性。为了更深入地了解tDCS，我们进行了计算机模拟，从一个均质化的三室头部模型开始，并逐步扩展到六室各向异性模型。首先，我们发现皮肤、颅骨海绵体和脑脊液腔室的通道效应。第二，电流矢量倾向于朝向最近的较高导电区域。第三，各向异性WM导电性导致电流在更平行于WM纤维束的方向上流动。第四，最高的皮层电流幅度不仅发现接近刺激部位。第五，中值脑电流密度随着与电极的距离的增加而减小。SignificanceOur结果使我们能够制定tDCS中体积导体建模的指导方针。我们建议对刺激电极和目标区域之间的主要组织进行准确建模，而对于高效而准确的建模，其他组织的精确表示不太重要。因为对于电生理学中的低频机制，准静态方法是合理的，所以我们的结果至少对低频（例如，低于100 Hz）经颅交流电刺激也是有效的。
ObjectiveWe investigate volume conduction effects in transcranial direct current stimulation (tDCS) and present a guideline for efficient and yet accurate volume conductor modeling in tDCS using our newly-developed finite element (FE) approach.ApproachWe developed a new, accurate and fast isoparametric FE approach for high-resolution geometry-adapted hexahedral meshes and tissue anisotropy. To attain a deeper insight into tDCS, we performed computer simulations, starting with a homogenized three-compartment head model and extending this step by step to a six-compartment anisotropic model.Main resultsWe are able to demonstrate important tDCS effects. First, we find channeling effects of the skin, the skull spongiosa and the cerebrospinal fluid compartments. Second, current vectors tend to be oriented towards the closest higher conducting region. Third, anisotropic WM conductivity causes current flow in directions more parallel to the WM fiber tracts. Fourth, the highest cortical current magnitudes are not only found close to the stimulation sites. Fifth, the median brain current density decreases with increasing distance from the electrodes.SignificanceOur results allow us to formulate a guideline for volume conductor modeling in tDCS. We recommend to accurately model the major tissues between the stimulating electrodes and the target areas, while for efficient yet accurate modeling, an exact representation of other tissues is less important. Because for the low-frequency regime in electrophysiology the quasi-static approach is justified, our results should also be valid for at least low-frequency (eg, below 100 Hz) transcranial alternating current stimulation.
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影响因子：
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