A spontaneous state of weakly correlated synaptic excitation and inhibition in visual cortex.
A spontaneous state of weakly correlated synaptic excitation and inhibition in visual cortex.
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DOI：
10.1016/j.neuroscience.2013.05.037
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发表时间：
2013-09-05
期刊：
影响因子：
3.3
通讯作者：
Priebe NJ
中科院分区：
文献类型：
--
作者：
Tan AY;Andoni S;Priebe NJ
Cortical spontaneous activity reflects an animal’s behavioral state and affects neural responses to sensory stimuli. The correlation between excitatory and inhibitory synaptic input to single neurons is a key parameter in models of cortical circuitry. Recent measurements demonstrated highly correlated synaptic excitation and inhibition during spontaneous “up-and-down” states, during which excitation accounted for approximately 80% of inhibitory variance. Here we report in vivo whole-cell estimates of the correlation between excitation and inhibition in the rat visual cortex under pentobarbital anesthesia, during which up-and-down states are absent. Excitation and inhibition are weakly correlated, relative to the up-and-down state: excitation accounts for less than 40% of inhibitory variance. Although these correlations are lower than when the circuit cycles between up-and-down states, both behaviors may arise from the same circuitry. Our observations provide evidence that different correlational patterns of excitation and inhibition underlie different cortical states.
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DOI：
10.1056/nejmra0808281
发表时间：
2010-12-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brown EN;Lydic R;Schiff ND
通讯作者：
Schiff ND
影响因子：
2.5
作者：
Compte, A;Sanchez-Vives, MV;Wang, XJ
通讯作者：
Wang, XJ
影响因子：
5.6
作者：
Claassen, J;Hirsch, LJ;Mayer, SA
通讯作者：
Mayer, SA
影响因子：
5.5
作者：
COLQUHOUN, D;JONAS, P;SAKMANN, B
通讯作者：
SAKMANN, B
影响因子：
5.3
作者：
Curto, Carina;Sakata, Shuzo;Harris, Kenneth D.
通讯作者：
Harris, Kenneth D.