The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer.
The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer.
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DOI：
10.1111/j.1474-9726.2009.00485.x
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发表时间：
2009-08
期刊：
影响因子：
7.8
通讯作者：
Savage SA
中科院分区：
文献类型：
--
作者：
Mirabello L;Huang WY;Wong JY;Chatterjee N;Reding D;Crawford ED;De Vivo I;Hayes RB;Savage SA
端粒由染色体末端的核苷酸重复序列和蛋白质复合物组成，它们对维持染色体完整性至关重要。一些研究表明，端粒较短的受试者患膀胱癌和肺癌的风险增加。与正常组织相比，高度上皮内瘤变和前列腺癌中的端粒较短。我们研究了与相对端粒长度相关的前列腺癌风险，通过定量PCR从612例晚期前列腺癌病例和1049例年龄匹配的PLCO癌症筛查试验的无癌症对照中分离出诊断前血沉棕黄层DNA。端粒长度作为连续变量和分类变量进行分析，并对潜在的混杂因素进行调整。在病例组和对照组中观察到端粒长度、年龄和吸烟状况之间的统计学显著负相关。端粒长度与前列腺癌风险无关（中位数，OR = 0.85，95%CI 0.67，1.08）;当端粒长度作为连续变量或按四分位数评估时，相关性相似。端粒长度与炎症相关因素，饮食，运动，体重指数和其他生活方式变量之间的关系进行了探索，因为其中许多以前与较短的端粒有关。健康的生活方式因素（即，较低的体重指数，更多的锻炼，戒烟，高水果和蔬菜的饮食）往往与更长的端粒长度有关。这项研究发现白细胞端粒长度与晚期前列腺癌风险之间没有统计学显著相关性。然而，端粒长度与健康生活方式的相关性被注意到，这表明这些因素在端粒生物学维护中的作用，并可能影响整体健康状况。
Telomeres consist of nucleotide repeats and a protein complex at chromosome ends that are essential to maintaining chromosomal integrity. Several studies have suggested that subjects with shorter telomeres are at increased risk of bladder and lung cancer. In comparison to normal tissues, telomeres are shorter in high-grade intraepithelial neoplasia and prostate cancer. We examined prostate cancer risk associated with relative telomere length as determined by quantitative PCR on pre-diagnostic buffy coat DNA isolated from 612 advanced prostate cancer cases and 1049 age-matched, cancer-free controls from the PLCO Cancer Screening Trial. Telomere length was analyzed as both a continuous and a categorical variable with adjustment for potential confounders. Statistically significant inverse correlations between telomere length, age and smoking status were observed in cases and controls. Telomere length was not associated with prostate cancer risk (at the median, OR = 0.85, 95% CI 0.67, 1.08); associations were similar when telomere length was evaluated as a continuous variable or by quartiles. The relationships between telomere length and inflammation-related factors, diet, exercise, body mass index, and other lifestyle variables were explored since many of these have previously been associated with shorter telomeres. Healthy lifestyle factors (i.e., lower BMI, more exercise, tobacco abstinence, diets high in fruit and vegetables) tended to be associated with greater telomere length. This study found no statistically significant association between leukocyte telomere length and advanced prostate cancer risk. However, correlations of telomere length with healthy lifestyles were noted, suggesting the role of these factors in telomere biology maintenance and potentially impacting overall health status.
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DOI：
10.1016/s0197-2456(00)00097-0
发表时间：
2000-12-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Gohagan, JK;Prorok, PC;Kramer, BS
通讯作者：
Kramer, BS
影响因子：
6.4
作者：
Cox, Brian;Sneyd, Mary J.;Skegg, David C. G.
通讯作者：
Skegg, David C. G.
影响因子：
2.5
作者：
Harris, Sarah E.;Deary, Ian J.;Shiels, Paul G.
通讯作者：
Shiels, Paul G.
影响因子：
6.6
作者：
Donaldson, L;Fordyce, C;Griffith, J
通讯作者：
Griffith, J
影响因子：
10.3
作者：
Ahn, Jiyoung;Peters, Ulrike;Hayes, Richard B.
通讯作者：
Hayes, Richard B.