Central Sites of Adenosine Action and Their Interaction with Various Drugs
Central Sites of Adenosine Action and Their Interaction with Various Drugs
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腺苷作用的中心位点及其与各种药物的相互作用
DOI：
10.1007/978-3-642-45619-0_7
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. Bisserbe
中科院分区：
文献类型：
--
作者：
P. Marangos;J. Deckert;J. Bisserbe
Adenosine receptors and adenosine uptake sites constitute interesting targets for the development of pharmacologic agents having sedative, anticonvulsant, antihypertensive and, possibly, anxiolytic properties. Specific probes now exist for both the receptor and the uptake site in brain. The available evidence indicates that either multiple populations or conformations of the receptor and uptake site are found in brain. Adenosine agonists bind to the receptor in a biphasic manner, suggesting the presence of two receptor subtypes, while antagonists apparently recognize a population of receptors that is only partially inhibited by various metal ions. We have recently tritium-labeled the adenosine uptake inhibitor dipyridamole (DPR) and show that it labels more adenosine uptake sites than [3H] nitrobenzylthioinosine (NBI), suggesting the existence of multiple subtypes of adenosine uptake sites. This is supported by the observation that NBI displaces [3H]DPR binding in a markedly biphasic manner. Autoradiographic analysis of [3H]DPR binding in guinea pig brain shows a heterogeneous distribution of sites, with areas such as the molecular layer of the cerebellum, superior colliculus, striatum, and cerebral cortex having high levels of both the receptor and uptake site. We suggest that those brain areas having high levels of both the adenosine receptor and uptake site may be sites of functionally relevant adenosinergic neuromodulation.
DOI：
10.1073/pnas.78.5.3260
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
SNYDER, SH;KATIMS, JJ;DALY, JW
通讯作者：
DALY, JW
鸟嘌呤核苷酸和阳离子对[3H]环己基腺苷和[3H]二乙基苯基黄嘌呤与脑膜中腺苷A1受体结合的调节。
影响因子：
3.6
作者：
Goodman,RR;Cooper,MJ;Gavish,M;Snyder,SH
通讯作者：
Snyder,SH
腺苷受体：放射自显影证据表明它们位于兴奋性神经元的轴突末端。
DOI：
10.1126/science.6302841
发表时间：
1983
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Goodman,RR;Kuhar,MJ;Hester,L;Snyder,SH
通讯作者：
Snyder,SH