Redox-active antibiotics enhance phosphorus bioavailability.

Redox-active antibiotics enhance phosphorus bioavailability.
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DOI:
10.1126/science.abd1515
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发表时间:
2021-03-05
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Newman DK
Newman DK
中科院分区:
其他
文献类型:
--
作者:
McRose DL;Newman DK

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抗生素的微生物产生很普遍,但是我们对它们在环境中的作用的理解是有限的。在这里,我们探讨了长期观察,即微生物在磷限制下增加了氧化还原活性抗生素的产生。磷的可用性是地球上所有生命所需的一种营养,可以通过通过氧化还原循环从铁矿物上吸附和释放来控制农业必不可少的磷。利用假单胞菌作为案例研究,我们表明苯嗪受磷调节并通过实验室和田间中的氧化铁的还原性溶解磷酸溶解,从而同时增加了微生物的生长。促苯胺只是磷调节抗生素的众多例子之一。我们的工作表明,在氧气活性抗生素中,在磷获取和骑自行车中具有广泛但以前未引起的作用。 抗生素增强了P的生物利用度。
Microbial production of antibiotics is common but our understanding of their roles in the environment is limited. Here, we explore long-standing observations that microbes increase production of redox-active antibiotics under phosphorus limitation. The availability of phosphorus, a nutrient required by all life on Earth and essential for agriculture, can be controlled by adsorption to and release from iron minerals via redox cycling. Using phenazine antibiotic production by pseudomonads as a case study, we show that phenazines are regulated by phosphorus and solubilize phosphate via reductive dissolution of iron oxides in the lab and field, concomitantly increasing microbial growth. Phenazines are just one of many examples of phosphorus-regulated antibiotics. Our work suggests a widespread but previously unappreciated role for redox-active antibiotics in phosphorus acquisition and cycling. Antibiotics enhance P bioavailability.
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发表时间: 2020-10-05
期刊: Current biology : CB
影响因子: --
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