Epstein-Barr virus growth/latency III program alters cellular microRNA expression.
Epstein-Barr virus growth/latency III program alters cellular microRNA expression.
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DOI：
10.1016/j.virol.2008.09.018
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发表时间：
2008-12-20
期刊：
影响因子：
3.7
通讯作者：
Flemington, Erik K.
中科院分区：
文献类型：
--
作者：
Cameron, Jennifer E.;Fewell, Claire;Yin, Qinyan;McBride, Jane;Wang, Xia;Lin, Zhen;Flemington, Erik K.
关键词：
eb病毒（EBV）与淋巴和上皮癌有关。最初的EBV感染改变淋巴细胞基因表达，随着病毒通过连续的潜伏期转录程序过渡，诱导细胞增殖和分化。细胞microRNAs （miRNAs）是信号通路的重要调节因子，与癌变有关。EBV利用细胞mirna的程度尚不清楚。通过微阵列分析和定量PCR，我们证实了III型EBV与I型EBV潜伏期中细胞mirna的差异表达，包括miR-21、miR-23a、miR-24、miR-27a、miR-34a、miR-146a和b以及miR-155的表达升高。相比之下，miR-28在III型潜伏期中表达较低。EBV介导的细胞mirna调控可能有助于EBV信号传导和相关癌症。
The Epstein-Barr virus (EBV) is associated with lymphoid and epithelial cancers. Initial EBV infection alters lymphocyte gene expression, inducing cellular proliferation and differentiation as the virus transitions through consecutive latency transcription programs. Cellular microRNAs (miRNAs) are important regulators of signaling pathways and are implicated in carcinogenesis. The extent to which EBV exploits cellular miRNAs is unknown. Using micro-array analysis and quantitative PCR, we demonstrate differential expression of cellular miRNAs in type III versus type I EBV latency including elevated expression of miR-21, miR-23a, miR-24, miR-27a, miR-34a, miR-146a and b, and miR-155. In contrast, miR-28 expression was found to be lower in type III latency. The EBV-mediated regulation of cellular miRNAs may contribute to EBV signaling and associated cancers.
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影响因子：
5.4
作者：
Cameron, Jennifer E.;Yin, Qinyan;Flemington, Erik K.
通讯作者：
Flemington, Erik K.
影响因子：
5.4
作者：
Miyashita, EM;Yang, B;ThorleyLawson, DA
通讯作者：
ThorleyLawson, DA
影响因子：
64.8
作者：
He, Lin;He, Xingyue;Hannon, Gregory J.
通讯作者：
Hannon, Gregory J.
影响因子：
4.8
作者：
Frankel, Lisa B.;Christoffersen, Nanna R.;Lund, Anders H.
通讯作者：
Lund, Anders H.
DOI：
10.1073/pnas.0602266103
发表时间：
2006-05-02
影响因子：
11.1
作者：
Costinean, S;Zanesi, N;Croce, CM
通讯作者：
Croce, CM