Rapid reversal of uremic neuropathy following renal transplantation in an adolescent.
Rapid reversal of uremic neuropathy following renal transplantation in an adolescent.
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DOI：
10.1111/j.1399-3046.2011.01630.x
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发表时间：
2012-11
影响因子：
1.3
通讯作者：
Kang PB
中科院分区：
文献类型：
--
作者：
Ho DT;Rodig NM;Kim HB;Lidov HG;Shapiro FD;Raju GP;Kang PB
成人尿毒症神经病变的临床和病理研究很多，但对儿童和青少年的这种疾病知之甚少。我们报告一位患有尿毒症性神经病变的青少年女性的临床、电生理及病理表现。电生理检查结果与主要轴突感觉运动性多发性神经病一致。腓肠神经活检显示髓鞘局灶性耗竭和轴突缺失。轴突变性伴继发性髓鞘改变似乎是本例的特征性病理，是我们所知的最年轻的神经活检资料。我们的病人经历了戏剧性的恢复肾移植后，类似的报告老年患者。
Clinical and pathologic studies on adults with uremic neuropathy are numerous, but less is known about this disorder in children and adolescents. We report the clinical, electrophysiologic, and pathologic findings in an adolescent female with uremic neuropathy. Electrophysiologic findings were consistent with a primarily axonal sensorimotor polyneuropathy. Sural nerve biopsy revealed areas of focal depletion in myelin sheaths and loss of axons. Axonal degeneration with secondary myelin changes appears to be the characteristic pathology in this case, one of the youngest to our knowledge for which nerve biopsy data are available. Our patient experienced dramatic recovery after renal transplantation, similar to reports of older patients.
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影响因子：
--
作者：
APPENZELLER, O;KORNFELD, M;MACGEE, J
通讯作者：
MACGEE, J
影响因子：
9.9
作者：
BOLTON, CF
通讯作者：
BOLTON, CF
影响因子：
3
作者：
HURKX, W;HULSTIJNDIRKMAAT, I;SCHRODER, C
通讯作者：
SCHRODER, C
影响因子：
9.9
作者：
SAID, G;BOUDIER, L;DRUEKE, T
通讯作者：
DRUEKE, T
影响因子：
158.5
作者：
BOLTON, CF;BALTZAN, MA;BALTZAN, RB
通讯作者：
BALTZAN, RB