Recipient Tregs: Can They Be Exploited for Successful Hematopoietic Stem Cell Transplant Outcomes?
Recipient Tregs: Can They Be Exploited for Successful Hematopoietic Stem Cell Transplant Outcomes?
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DOI：
10.3389/fimmu.2022.932527
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发表时间：
2022
影响因子：
7.3
通讯作者：
Levy, Robert B.
中科院分区：
文献类型：
--
作者：
Copsel, Sabrina N.;Wolf, Dietlinde;Pfeiffer, Brent;Barreras, Henry;Perez, Victor L.;Levy, Robert B.
人和小鼠 CD4+FoxP3+ T 细胞 (Treg) 包含非冗余的调节区室，可维持自身耐受性，并被发现在自身免疫性疾病和移植（包括同种异体造血干细胞移植 (allo-HSCT)）中具有潜在的治疗用途。有大量文献质疑供体来源的 Tregs 在预防移植物抗宿主病 (GVHD) 中的应用。本次小型回顾将重点关注移植后持续存在的受体 Tregs。尽管对 HSCT 后 2 个月低剂量 IL-2 的患者进行治疗令人鼓舞，但在移植后早期操纵受体中的 Treg 具有挑战性，部分可能是支持 Treg 扩张所需的微环境受损的间接后果，而对此我们知之甚少。本综述将讨论 HSCT（融合蛋白，mAb）之前和之后体内操纵受体 Tregs 的潜力。将考虑规避供体/受体外周血采集、细胞培养和离体 Treg 扩增的策略，以实现 Tregs 的转化应用，以改善 HSCT 的结果。
Human and mouse CD4+FoxP3+ T cells (Tregs) comprise non-redundant regulatory compartments which maintain self-tolerance and have been found to be of potential therapeutic usefulness in autoimmune disorders and transplants including allogeneic hematopoietic stem cell transplantation (allo-HSCT). There is substantial literature interrogating the application of donor derived Tregs for the prevention of graft versus host disease (GVHD). This Mini-Review will focus on the recipient’s Tregs which persist post-transplant. Although treatment in patients with low dose IL-2 months post-HSCT are encouraging, manipulating Tregs in recipients early post-transplant is challenging, in part likely an indirect consequence of damage to the microenvironment required to support Treg expansion of which little is understood. This review will discuss the potential for manipulating recipient Tregs in vivo prior to and after HSCT (fusion proteins, mAbs). Strategies that would circumvent donor/recipient peripheral blood harvest, cell culture and ex-vivo Treg expansion will be considered for the translational application of Tregs to improve HSCT outcomes.
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影响因子：
5.4
作者：
Bayer, Allison L.;Chirinos, Jackeline;Cabello, Cecilia;Yang, Jing;Matsutani, Takaji;Malek, Thomas R.;Levy, Robert B.
通讯作者：
Levy, Robert B.
DOI：
10.1084/jem.20151563
发表时间：
2016-08-22
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chopra M;Biehl M;Steinfatt T;Brandl A;Kums J;Amich J;Vaeth M;Kuen J;Holtappels R;Podlech J;Mottok A;Kraus S;Jordán-Garrote AL;Bäuerlein CA;Brede C;Ribechini E;Fick A;Seher A;Polz J;Ottmüller KJ;Baker J;Nishikii H;Ritz M;Mattenheimer K;Schwinn S;Winter T;Schäfer V;Krappmann S;Einsele H;Müller TD;Reddehase MJ;Lutz MB;Männel DN;Berberich-Siebelt F;Wajant H;Beilhack A
通讯作者：
Beilhack A
影响因子：
7.3
作者：
Beres AJ;Drobyski WR
通讯作者：
Drobyski WR
影响因子：
20.3
作者：
Bayer, Allison L.;Jones, Monica;Levy, Robert B.
通讯作者：
Levy, Robert B.
影响因子：
4.3
作者：
Copsel, Sabrina;Wolf, Dietlinde;Levy, Robert B.
通讯作者：
Levy, Robert B.