Altered functional brain dynamics in chromosome 22q11.2 deletion syndrome during facial affect processing.
Altered functional brain dynamics in chromosome 22q11.2 deletion syndrome during facial affect processing.
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DOI：
10.1038/s41380-021-01302-y
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发表时间：
2022-03
影响因子：
11
通讯作者：
Bassett, Dani S.
中科院分区：
文献类型：
--
作者：
Cornblath, Eli J.;Mahadevan, Arun;He, Xiaosong;Ruparel, Kosha;Lydon-Staley, David M.;Moore, Tyler M.;Gur, Ruben C.;Zackai, Elaine H.;Emanuel, Beverly;McDonald-McGinn, Donna M.;Wolf, Daniel H.;Satterthwaite, Theodore D.;Roalf, David R.;Gur, Raquel E.;Bassett, Dani S.
染色体22q11.2缺失综合征（22q11.2DS）是一种多系统疾病，与多种先天性异常，可变的医学特征和神经发育差异相关，导致不同的精神病表型，包括面部记忆和社会认知的明显缺陷。22q11.2DS患者的神经影像学显示，在面部情感处理任务中，BOLD功能磁共振成像激活与匹配对照组相比存在差异。然而，尚未在22 q11.2DS中使用BOLD fMRI研究面部情感处理期间大脑区域之间的时变相互作用。我们应用约束主成分分析，以确定时间重叠的大脑激活模式，从BOLD功能磁共振成像数据期间获得的情绪识别任务，从58个人与22q11.2DS和58个年龄，种族和性别匹配的健康对照。在22q11.2DS患者中，延迟的额叶运动反馈信号减少，杏仁核、海马和内嗅皮层的延迟情绪记忆信号也减少。在22q11.2DS中，运动和视觉皮层的早期任务相关参与以及与显著性相关的岛叶激活相对保留。在22q11.2DS样本中，岛叶激活与任务表现相关。皮质表面积的差异，但不是皮质厚度，显示空间对齐与面部处理相关的激活模式。这些研究结果表明，相对于匹配的控制，主要的视觉处理和岛屿功能是相对完整的个人与22q11.22DS，而运动反馈，面部处理和情绪记忆过程的影响更大。这些见解可能有助于为潜在的干预目标提供信息，并增强22q11.2DS中认知功能障碍的神经影像学指标的特异性。
Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a multisystem disorder associated with multiple congenital anomalies, variable medical features, and neurodevelopmental differences resulting in diverse psychiatric phenotypes, including marked deficits in facial memory and social cognition. Neuroimaging in individuals with 22q11.2DS has revealed differences relative to matched controls in BOLD fMRI activation during facial affect processing tasks. However, time-varying interactions between brain areas during facial affect processing have not yet been studied with BOLD fMRI in 22q11.2DS. We applied constrained principal component analysis to identify temporally overlapping brain activation patterns from BOLD fMRI data acquired during an emotion identification task from 58 individuals with 22q11.2DS and 58 age-, race-, and sex-matched healthy controls. Delayed frontal-motor feedback signals were diminished in individuals with 22q11.2DS, as were delayed emotional memory signals engaging amygdala, hippocampus, and entorhinal cortex. Early task-related engagement of motor and visual cortices and salience-related insular activation were relatively preserved in 22q11.2DS. Insular activation was associated with task performance within the 22q11.2DS sample. Differences in cortical surface area, but not cortical thickness, showed spatial alignment with an activation pattern associated with face processing. These findings suggest that relative to matched controls, primary visual processing and insular function are relatively intact in individuals with 22q11.22DS, while motor feedback, face processing, and emotional memory processes are more affected. Such insights may help inform potential interventional targets and enhance the specificity of neuroimaging indices of cognitive dysfunction in 22q11.2DS.
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影响因子：
5.7
作者：
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作者：
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