Cortical responses to touch reflect subcortical integration of LTMR signals.
Cortical responses to touch reflect subcortical integration of LTMR signals.
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DOI：
10.1038/s41586-021-04094-x
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发表时间：
2021-12
期刊：
影响因子：
64.8
通讯作者：
中科院分区：
文献类型：
--
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目前解释皮肤机械感受器发出的信号如何产生触摸表征的模型是基于机械感受器亚型和躯体感觉皮质神经元的触觉反应的比较。在这里，我们使用小鼠的遗传操作来研究外周机械感受器亚型对皮质触摸反应的贡献。皮层神经元对皮肤压痕表现出非常均匀和瞬时的反应，类似于快速适应(RA)低阈值机械感受器(LTMR)反应。来自AβRA-LTMR和Aβ缓慢适应(SA-)LTMR的信号的同时中断消除了皮质对光压痕力的反应。然而，任一LTMR亚型的破坏单独引起了皮质敏感性的相反变化，但在其他方面基本上没有改变触觉反应，表明这两种亚型都有助于正常的皮质反应。AβRA-LTMR或AβSA-LTMR的单个动作电位的选择性光遗传激活在大多数机械敏感的皮质神经元中驱动低潜伏期反应。同样，大多数体感丘脑神经元也由AβRA-LTMR或AβSA-LTMR的激活所驱动。这些发现支持一种模型，在该模型中，来自生理上不同的机械感受器亚型的信号被广泛整合并在皮质下躯体感觉系统中转换，以产生触摸的皮质表征。
Current models to explain how signals emanating from cutaneous mechanoreceptors generate representations of touch are based on comparisons of the tactile responses of mechanoreceptor subtypes and neurons in somatosensory cortex. Here, we used mouse genetic manipulations to investigate the contributions of peripheral mechanoreceptor subtypes to cortical responses to touch. Cortical neurons exhibited remarkably homogeneous and transient responses to skin indentation that resembled rapidly adapting (RA) low-threshold mechanoreceptor (LTMR) responses. Concurrent disruption of signals from both Aβ RA-LTMRs and Aβ slowly adapting (SA-) LTMRs eliminated cortical responses to light indentation forces. However, disruption of either LTMR subtype alone caused opposite shifts in cortical sensitivity but otherwise largely unaltered tactile responses, indicating that both subtypes contribute to normal cortical responses. Selective optogenetic activation of single action potentials in Aβ RA-LTMRs or Aβ SA-LTMRs drove low-latency responses in the majority of mechanically sensitive cortical neurons. Likewise, most somatosensory thalamic neurons were also driven by activation of Aβ RA-LTMRs or Aβ SA-LTMRs. These findings support a model in which signals from physiologically distinct mechanoreceptor subtypes are extensively integrated and transformed within the subcortical somatosensory system to generate cortical representations of touch.
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影响因子：
2.4
作者：
Magri C;Whittingstall K;Singh V;Logothetis NK;Panzeri S
通讯作者：
Panzeri S
影响因子：
64.5
作者：
Li L;Rutlin M;Abraira VE;Cassidy C;Kus L;Gong S;Jankowski MP;Luo W;Heintz N;Koerber HR;Woodbury CJ;Ginty DD
通讯作者：
Ginty DD
影响因子：
25
作者：
Lin, John Y.;Knutsen, Per Magne;Muller, Arnaud;Kleinfeld, David;Tsien, Roger Y.
通讯作者：
Tsien, Roger Y.
DOI：
10.1073/pnas.1014411108
发表时间：
2011-02-22
影响因子：
11.1
作者：
da Silva, Susana;Hasegawa, Hiroshi;Wang, Fan
通讯作者：
Wang, Fan
DOI：
10.1126/science.1228258
发表时间：
2012-12-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Liu Y;Rutlin M;Huang S;Barrick CA;Wang F;Jones KR;Tessarollo L;Ginty DD
通讯作者：
Ginty DD