Transplantation of periaortic adipose tissue from angiotensin receptor blocker-treated mice markedly ameliorates atherosclerosis development in apoE–/– mice
Transplantation of periaortic adipose tissue from angiotensin receptor blocker-treated mice markedly ameliorates atherosclerosis development in apoE–/– mice
复制标题
血管紧张素受体阻滞剂治疗小鼠的主动脉周围脂肪组织移植显着改善了 apoE–/– 小鼠的动脉粥样硬化发展
DOI：
10.1177/1470320314552434
复制
发表时间：
2015
影响因子：
2.9
通讯作者：
H. Yamada
中科院分区：
文献类型：
--
作者：
Daisuke Irie;Hiroyuki Kawahito;Noriyuki Wakana;Taku Kato;S. Kishida;M. Kikai;T. Ogata;K. Ikeda;T. Ueyama;S. Matoba;H. Yamada
背景：血管周围脂肪组织与血管反应性有关；然而，其对动脉粥样硬化的影响尚不明确。方法和结果：我们研究了高胆固醇饮食（HCD）对apoE缺陷（apoE - / -）小鼠胸主动脉周围脂肪组织（tPAT）表型改变的影响。饲喂HCD的apoE - / -小鼠肾素血管紧张素系统组分和巨噬细胞标记物的基因表达显著高于饲喂CD的apoE - / -小鼠。这些变化在血管紧张素II （AngII）受体阻断剂（ARB）处理的apoE - / -小鼠和AngII型1 （AT1）受体缺陷的apoE - / - (Agtr1 - / - /apoE - / -)小鼠中均不存在。为了评估其对动脉粥样硬化的影响，我们将tPAT移植到apoE - / -小鼠腹主动脉远端。移植的tPAT来自于喂食CD （tPAT-CD/apoE - / -、tPAT-CD/Agtr1 - / - /apoE - / -）、HCD （tPAT-HCD/apoE - / -、tPAT-HCD/Agtr1 - / - /apoE - / -）或HCD联合ARB （tPAT-HCD/ARB/apoE - / -）小鼠的apoE - / -和Agtr1 - / -)。移植后4周，tPAT-HCD/apoE - / -小鼠主动脉油红o阳性面积明显高于tPAT-CD/apoE - / -小鼠。这种变化在tPAT-HCD/ARB/apoE - / -和tPAT-HCD/Agtr1 - / - /apoE - / -小鼠中不存在。结论：我们的研究结果表明，AT1受体在hcd诱导的tPAT表型改变中起着至关重要的作用，对其进行调节可以对动脉粥样硬化产生有益的影响。
Background: Perivascular adipose tissue is implicated in vasoreactivity; however, its effect on atherosclerosis remains undefined. Methods and results: We examined the effect of a high-cholesterol diet (HCD) on phenotypic alterations of the thoracic periaortic adipose tissue (tPAT) in apoE-deficient (apoE–/–) mice. Gene expression of the components of the renin angiotensin system and that of macrophage markers were significantly higher in apoE–/– mice fed an HCD than in those fed a chow diet (CD). These changes were absent both in angiotensin II (AngII) receptor blocker (ARB)-treated apoE–/– mice and in Ang II type 1 (AT1) receptor-deficient apoE–/– (Agtr1–/–/apoE–/–) mice. To evaluate their effect on atherosclerosis, we transplanted tPAT into apoE–/– mice alongside the distal abdominal aorta. Transplanted tPAT was harvested from apoE–/– and Agtr1–/–/apoE–/– mice fed a CD (tPAT-CD/apoE–/–, tPAT-CD/Agtr1–/–/apoE–/–), HCD (tPAT-HCD/apoE–/–, tPAT-HCD/Agtr1–/–/apoE–/–), or HCD in combination with ARB treatment (tPAT-HCD/ARB/apoE–/–). Four weeks after transplantation, a significantly increased oil red O-positive area was observed in the aorta of tPAT-HCD/apoE–/– mice than in tPAT-CD/apoE–/– mice. Such a change was absent in tPAT-HCD/ARB/apoE–/– and tPAT-HCD/Agtr1–/–/apoE–/– mice. Conclusions: Our findings demonstrated that AT1 receptor plays a crucial role in HCD-induced phenotypic alterations of tPAT, modulation of which could exert beneficial effects on atherosclerosis.
DOI：
10.1152/ajpheart.00376.2011
发表时间：
2011-10-01
影响因子：
4.8
作者：
Fitzgibbons, Timothy P.;Kogan, Sophia;Czech, Michael P.
通讯作者：
Czech, Michael P.
DOI：
10.1161/atvbaha.114.303030
发表时间：
2014-08
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Omar A;Chatterjee TK;Tang Y;Hui DY;Weintraub NL
通讯作者：
Weintraub NL
影响因子：
5.8
作者：
Olson, Nels C.;Callas, Peter W.;Tracy, Russell P.
通讯作者：
Tracy, Russell P.