Interplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritis.
Interplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritis.
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DOI：
10.3390/ijms141019805
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发表时间：
2013-09-30
影响因子：
5.6
通讯作者：
Nam JS
中科院分区：
文献类型：
--
作者：
Sharma AR;Jagga S;Lee SS;Nam JS
骨关节炎（OA）是一种常见的使人衰弱的关节疾病，影响大部分人口，具有显著的残疾和生活质量受损。在OA期间，包括软骨和软骨下骨的关节的功能单元经历不受控制的分解代谢和合成代谢重塑过程以适应局部生化和生物信号。软骨和软骨下骨的变化不仅是OA的继发性表现，而且是疾病的活性成分，导致其严重性。OA期间关节中血管化增加和微裂纹形成表明分子从软骨到骨的促进作用，反之亦然。最近的研究结果支持这样的观点，即软骨和软骨下骨可以通过调节病理条件下关节内稳态的信号通路相互通信。本文就OA发生发展过程中控制软骨-骨生化单位和参与软骨-软骨下骨细胞间通讯的主要信号通路作一综述。了解在生理和病理条件下调节软骨细胞和成骨细胞功能行为的分子通讯可能会导致开发更有效的治疗OA患者的策略。
Osteoarthritis (OA) is a common debilitating joint disorder, affecting large sections of the population with significant disability and impaired quality of life. During OA, functional units of joints comprising cartilage and subchondral bone undergo uncontrolled catabolic and anabolic remodeling processes to adapt to local biochemical and biological signals. Changes in cartilage and subchondral bone are not merely secondary manifestations of OA but are active components of the disease, contributing to its severity. Increased vascularization and formation of microcracks in joints during OA have suggested the facilitation of molecules from cartilage to bone and vice versa. Observations from recent studies support the view that both cartilage and subchondral bone can communicate with each other through regulation of signaling pathways for joint homeostasis under pathological conditions. In this review we have tried to summarize the current knowledge on the major signaling pathways that could control the cartilage-bone biochemical unit in joints and participate in intercellular communication between cartilage and subchondral bone during the process of OA. An understanding of molecular communication that regulates the functional behavior of chondrocytes and osteoblasts in both physiological and pathological conditions may lead to development of more effective strategies for treating OA patients.
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影响因子：
7
作者：
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通讯作者：
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