Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin.
Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin.
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DOI：
10.1038/bcj.2014.16
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发表时间：
2014-03-21
影响因子：
12.8
通讯作者：
Holien, T.
中科院分区：
文献类型：
--
作者：
Olsen, O. E.;Wader, K. F.;Misund, K.;Vatsveen, T. K.;Ro, T. B.;Mylin, A. K.;Turesson, I.;Stordal, B. F.;Moen, S. H.;Standal, T.;Waage, A.;Sundan, A.;Holien, T.
多发性骨髓瘤主要位于骨髓中的浆细胞的恶性肿瘤在人类血清中抑制癌细胞生长的人血清中，我们在这里表明，骨髓瘤患者的BMP-9水平升高健康对照（中位数为110 pg/mL，范围为8–359）。骨髓瘤细胞中诱导的凋亡与C-Myc下调有关。骨髓瘤细胞如何逃避多发性骨髓瘤中BMP-9的肿瘤活性的一种机制。
Multiple myeloma is a malignancy of plasma cells predominantly located in the bone marrow. A number of bone morphogenetic proteins (BMPs) induce apoptosis in myeloma cells in vitro, and with this study we add BMP-9 to the list. BMP-9 has been found in human serum at concentrations that inhibit cancer cell growth in vitro. We here show that the level of BMP-9 in serum was elevated in myeloma patients (median 176 pg/ml, range 8–809) compared with healthy controls (median 110 pg/ml, range 8–359). BMP-9 was also present in the bone marrow and was able to induce apoptosis in 4 out of 11 primary myeloma cell samples by signaling through ALK2. BMP-9-induced apoptosis in myeloma cells was associated with c-MYC downregulation. The effects of BMP-9 were counteracted by membrane-bound (CD105) or soluble endoglin present in the bone marrow microenvironment, suggesting a mechanism for how myeloma cells can evade the tumor suppressing activity of BMP-9 in multiple myeloma.
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影响因子：
2.6
作者：
Jonker, L;Arthur, HM
通讯作者：
Arthur, HM
影响因子：
4.8
作者：
Castonguay, Roselyne;Werner, Eric D.;Grinberg, Asya V.
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Grinberg, Asya V.
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Baughn, Linda B.;Di Liberto, Maurizio;Chen-Kiang, Selina
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Chen-Kiang, Selina
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Kang, Q;Sun, MH;He, TC
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He, TC
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Barbara, NP;Wrana, JL;Letarte, M
通讯作者：
Letarte, M