When orthologs diverge between human and mouse.

When orthologs diverge between human and mouse.
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DOI:
10.1093/bib/bbr031
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发表时间:
2011-09
影响因子:
9.5
通讯作者:
Robinson-Rechavi M
Robinson-Rechavi M
中科院分区:
生物学2区
文献类型:
--
作者:
Gharib WH;Robinson-Rechavi M

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尽管通常假设直系同源物通常具有相同的功能,但已经有各种关于直系同源物之间的分歧的报道,即使是在像哺乳动物这样接近的物种之间。小鼠和人类的比较特别有趣,因为小鼠经常被用作了解人类生物学的模式生物。我们回顾了人类和小鼠的orthopathy基因之间的分歧的证据的文献,并讨论它在生物医学研究的背景下。
Despite the common assumption that orthologs usually share the same function, there have been various reports of divergence between orthologs, even among species as close as mammals. The comparison of mouse and human is of special interest, because mouse is often used as a model organism to understand human biology. We review the literature on evidence for divergence between human and mouse orthologous genes, and discuss it in the context of biomedical research.
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