Large-scale assignment of orthology: back to phylogenetics?
Large-scale assignment of orthology: back to phylogenetics?
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DOI:
10.1186/gb-2008-9-10-235
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发表时间:
2008-10-30
期刊:
影响因子:
12.3
通讯作者:
Gabaldón T
中科院分区:
文献类型:
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作者:
Gabaldón T
Automated use of phylogenetic trees to deduce orthology relationships in proteins. Reliable orthology prediction is central to comparative genomics. Although orthology is defined by phylogenetic criteria, most automated prediction methods are based on pairwise sequence comparisons. Recently, automated phylogeny-based orthology prediction has emerged as a feasible alternative for genome-wide studies.
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