Quantifying microcalcification activity in the thoracic aorta.
Quantifying microcalcification activity in the thoracic aorta.
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DOI：
10.1007/s12350-020-02458-w
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发表时间：
2022-06
期刊：
影响因子：
--
通讯作者：
Dweck MR
中科院分区：
文献类型：
--
作者：
Fletcher AJ;Lembo M;Kwiecinski J;Syed MBJ;Nash J;Tzolos E;Bing R;Cadet S;MacNaught G;van Beek EJR;Moss AJ;Doris MK;Walker NL;Dey D;Adamson PD;Newby DE;Slomka PJ;Dweck MR
用于量化主动脉中的正电子发射断层扫描（PET）摄取的标准方法是耗时的，并且可能不能反映总体血管活动。我们描述了主动脉微钙化活性（AMA），一种新的方法，用于定量18F-氟化钠（18F-NaF）在胸主动脉的摄取。20例患者接受了两次混合18F-NaF PET和计算机断层扫描（CT）的胸主动脉扫描，间隔不到三周。由两名经过培训的操作员计算AMA以及最大（TBRmax）和平均（TBRmean）组织与背景比。评估了观察者内重复性、观察者间重复性和扫描再扫描重复性。将每种18F-NaF定量方法与经验证的心血管风险评分进行比较。主动脉微钙化活动表现出极好的观察者内（组内相关系数0.98）和观察者间（组内相关系数0.97）重复性，具有非常好的扫描重扫描再现性（组内相关系数0.86），与先前描述的TBRmean和TBRmax方法相似。AMA分析比标准TBR评估快得多（3.4分钟对15.1分钟，P<0.0001）。AMA与Fragrance卒中风险评分和Fragrance硬冠状动脉心脏病风险评分相关。AMA是一种简单、快速和可重复的方法，用于量化整个升主动脉和主动脉弓的18F-NaF摄取，并与心血管风险评分相关。本文的在线版本（10.1007/s12350-020-02458-w）包含补充材料，可供授权用户使用。
Standard methods for quantifying positron emission tomography (PET) uptake in the aorta are time consuming and may not reflect overall vessel activity. We describe aortic microcalcification activity (AMA), a novel method for quantifying 18F-sodium fluoride (18F-NaF) uptake in the thoracic aorta. Twenty patients underwent two hybrid 18F-NaF PET and computed tomography (CT) scans of the thoracic aorta less than three weeks apart. AMA, as well as maximum (TBRmax) and mean (TBRmean) tissue to background ratios, were calculated by two trained operators. Intra-observer repeatability, inter-observer repeatability and scan-rescan reproducibility were assessed. Each 18F-NaF quantification method was compared to validated cardiovascular risk scores. Aortic microcalcification activity demonstrated excellent intra-observer (intraclass correlation coefficient 0.98) and inter-observer (intraclass correlation coefficient 0.97) repeatability with very good scan-rescan reproducibility (intraclass correlation coefficient 0.86) which were similar to previously described TBRmean and TBRmax methods. AMA analysis was much quicker to perform than standard TBR assessment (3.4min versus 15.1min, P<0.0001). AMA was correlated with Framingham stroke risk scores and Framingham risk score for hard cononary heart disease. AMA is a simple, rapid and reproducible method of quantifying global 18F-NaF uptake across the ascending aorta and aortic arch that correlates with cardiovascular risk scores. The online version of this article (10.1007/s12350-020-02458-w) contains supplementary material, which is available to authorized users.
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影响因子：
37.8
作者：
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者：
Kannel, WB
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4.4
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作者：
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影响因子：
168.9
作者：
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通讯作者：
Tawakol, Ahmed