Transplanted infections: donor-to-host transmission with the allograft.
Transplanted infections: donor-to-host transmission with the allograft.
复制标题
移植感染：通过同种异体移植物进行供体至宿主的传播。
DOI：
--
复制
发表时间：
1989
影响因子：
39.2
通讯作者：
K. Gottesdiener
中科院分区：
文献类型：
--
作者：
K. Gottesdiener
目的
评估器官捐赠者向移植受者传播感染病原体的情况，并评估感染的危险因素，主要是肾、角膜和心脏移植的受者。
数据识别
对MEDLINE和Paperchase进行计算机文献检索，直至1988年1月，对已识别文章的参考文献进行广泛综述，并对主要临床和移植期刊进行综述，直至1988年6月。
研究选择
选择和审查了所有报告了可能的供体向接受者传播感染的病例报告和研究。
数据提取
根据供者和受者信息的完整性和其他感染原因的可能性，判断每一例报告或患者从供者到接受者的传播是可能的、可能的或被证实的。
数据合成的结果
真正的供者传播感染可与人类免疫缺陷病毒、巨细胞病毒、单纯疱疹病毒、爱泼斯坦-巴尔病毒、狂犬病病毒、引起克雅氏病的病毒以及乙肝病毒一起发生。它也可以发生在许多常见的需氧细菌中，尽管同种异体移植物传播的细菌感染更多地是由收获和加工过程中的污染引起的。真菌和酵母菌以及弓形虫病的传播频率较低，分枝杆菌感染、疟疾、锥虫病和强形虫病与捐赠者器官一起移植的情况很少见。
结论
感染可以通过捐赠者的器官传播给接受者，但在加工和收获过程中对器官的污染较为常见，可能会导致接受者的严重感染，特别是如果污染是由更具毒性的有机体的子集之一造成的。真正的捐赠者传播感染虽然罕见，但可以通过仔细的捐赠者筛查来减少，这应该包括对感染证据的临床和流行病学评估，以及明智的实验室测试。
PURPOSE
To evaluate the transmission of infectious agents from organ donors to transplant recipients, and to assess risk factors for transmission, primarily in recipients of kidney, cornea, and heart allografts.
DATA IDENTIFICATION
Computerized literature searches of MEDLINE and PAPERCHASE through January 1988, extensive review of references from identified articles, and review of major clinical and transplantation journals through June 1988.
STUDY SELECTION
All case reports and studies that reported a possible donor-to-recipient transmission of infection were selected and reviewed.
DATA EXTRACTION
Each case report or patient series of donor-to-recipient transmission was judged as possible, probable, or proven depending on the completeness of donor and recipient information available and the likelihood of alternate causes of infection.
RESULTS OF DATA SYNTHESIS
True donor-transmitted infection can occur with viruses including human immunodeficiency virus, cytomegalovirus, herpes simplex, Epstein-Barr, rabies, the virus causing Creutzfeldt-Jakob disease, and with hepatitis B virus. It can also occur with many common aerobic bacteria, although allograft-transmitted bacterial infection is more often caused by contamination during harvesting and processing. Fungi and yeast, as well as toxoplasmosis, have been transmitted less frequently, and there have been rare instances when mycobacterial infection, malaria, trypanosomiasis, and strongyloidiasis have been transplanted with the donor organ.
CONCLUSIONS
Infection can be transmitted with a donor organ to the recipient, but contamination of the organ during processing and harvesting is commoner and may lead to severe infection in the recipient, especially if contamination is by one of a subset of more virulent organisms. True donor-transmitted infection, although rare, can be reduced by careful donor screening, which should include clinical and epidemiologic assessment for evidence of infection, as well as judicious laboratory testing.
登录
查看更多内容
肾移植受者发生巨细胞病毒相关肺炎的危险因素。
DOI：
10.1093/infdis/148.6.1121
发表时间：
1983
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Peterson,PK;BalfourJr,HH;Fryd,DS;Ferguson,R;Kronenberg,R;Simmons,RL
通讯作者：
Simmons,RL
心脏移植受者的特异性细胞介导的免疫和疱疹病毒感染。
DOI：
10.1016/0002-9343(82)90410-7
发表时间：
1982
期刊：
The American journal of medicine
影响因子：
--
作者：
Pollard,RB;Arvin,AM;Gamberg,P;Rand,KH;Gallagher,JG;Merigan,TC
通讯作者：
Merigan,TC
与骨髓移植相关的巨细胞病毒感染的分子流行病学。
影响因子：
39.2
作者：
Winston,DJ;Huang,ES;Miller,MJ;Lin,CH;Ho,WG;Gale,RP;Champlin,RE
通讯作者：
Champlin,RE
121 例肝移植受者巨细胞病毒和其他疱疹病毒感染：通过捐赠器官传播以及 OKT3 抗体的作用。
DOI：
10.1093/infdis/158.1.124
发表时间：
1988
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Singh,N;Dummer,JS;Kusne,S;Breinig,MK;Armstrong,JA;Makowka,L;Starzl,TE;Ho,M
通讯作者：
Ho,M
使用巨细胞病毒免疫球蛋白预防肾移植受者的巨细胞病毒病。
DOI：
10.1056/nejm198710223171703
发表时间：
1987
期刊：
The New England journal of medicine
影响因子：
--
作者：
Snydman,DR;Werner,BG;Heinze-Lacey,B;Berardi,VP;Tilney,NL;Kirkman,RL;Milford,EL;Cho,SI;BushJr,HL;Levey,AS
通讯作者：
Levey,AS